rhEGF联合Q开关翠绿宝石激光治疗色素增加性皮肤病疗效及对皮肤屏障功能的影响  

Effect of rhEGF Combined with Q-switched Turquoise Laser on Skin Barrier Function of Hyperpigmented Dermatosis

作　　者：洪声 吴建华 王再兴[1] HONG Sheng;WU Jianhua;WANG Zaixing(Department of Dermatology,the First Affi liated Hospital of Anhui Medical University,Hefei 230032,Anhui,China;Department of Dermatology,the First Affi liated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]安徽医科大学第一附属医院皮肤科,安徽合肥230032 [2]海军军医大学第一附属医院皮肤科,上海200433

出　　处：《中国美容医学》2022年第4期5-8,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察rhEGF联合Q开关翠绿宝石激光治疗色素增加性皮肤病的疗效,及其对患者皮肤屏障功能的影响。方法:选取2018年10月-2019年12月于笔者医院诊疗的色素增加性皮肤病患者268例,按照随机数字表法分为对照组和观察组,每组134例。对照组给予波长为755 nm的Q开关翠绿宝石激光治疗,观察组在对照组治疗基础上给予外敷rhEGF凝胶。两组患者均治疗3次,每次间隔3~6个月。比较两组患者疗效,两组治疗前后皮肤屏障功能[皮肤经皮水分丢失(TEWL)、角质层的含水量、pH值、乳酸刺激评分、a值及粘脱蛋白质含量],色素沉着评分及色素沉着面积,比较两组不良反应发生率。结果:观察组及对照组有效率分别为92.54%和81.34%,观察组有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者a值、pH值、TEWL、角质层含水量、粘脱蛋白质含量及乳酸刺激评分差异无统计学意义(P>0.05);治疗后,观察组a值、TEWL、粘脱蛋白质含量及乳酸刺激评分低于对照组,差异有统计学意义(P<0.05),角质层含水量高于对照组,差异有统计学意义(P<0.05)。治疗后,两组pH值改变差异无统计学意义(P>0.05)。治疗前,两组患者色素沉着评分及色素沉着面积比较,差异无统计学意义(P>0.05);治疗后,观察组色素沉着评分及色素沉着面积均低于对照组,观察组结痂时间、愈合时间及痂皮脱落时间均短于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率分别为0.75%和5.22%,差异有统计学意义(χ^(2)=4.690,P=0.030)。结论:rhEGF联合Q开关翠绿宝石激光治疗色素增加性皮肤具有良好疗效,可有效保护皮肤屏障功能,减少皮肤色素沉着,加速愈合且安全性高。Objective To observe the efficacy of rhEGF combined with switch emerald laser in the treatment of pigmented skin and its effect on pigmentation and skin barrier function.Methods From October 2018 to December 2019,268 cases of pigmentincreasing dermatosis were divided into control group and observation group according to random number table method,134cases in each group.The control group was given a wavelength of 755 nm Q the emerald laser instrument was laser according to the type of hyperpigmented dermatosis in the patients,and the observation group was given external application rhEGF gel on the basis of the control group.The patients in both groups were treated 3 times at intervals of 3-6 months.The efficacy of the two groups was compared.skin barrier function[lost water (TEWL) in the skin,cuticle water content,pH value,lactate stimulation score,a value and mucin content],pigmentation score,and pigmentation area were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups.Results The effective rates of observation group and control group were 92.54%and 81.34%respectively.The effective rate of observation group was higher than that of control group,difference was statistically significant(P<0.05).There was no difference in a value,pH value,water content of TEWL,cuticle,mucin content and lactate stimulation score between the two groups before treatment (P>0.05).The a value,TEWL,protein content and lactic acid stimulation score in the observation group were lower than those in the control group,difference was statistically significant(P<0.05).The water content of cuticle was higher than that of control group,difference was statistically significant(P<0.05).There was no difference in pH value between the two groups after treatment(P>0.05).Before treatment,there was no difference in pigmentation score and pigmentation area between the two groups(P>0.05).After treatment,the pigmentation score and pigmentation area in the observation group were

关 键 词：重组人表皮生长因子 Q开关翠绿宝石激光 色素增加性皮肤病 色素沉着 皮肤屏障功能 

分 类 号：R364.23[医药卫生—病理学]