Evidence-based approach to management of hepatic encephalopathy in adults  

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作  者:Gilles Jadd Hoilat Fathima Keshia Suhail Talal Adhami Savio John 

机构地区:[1]Department of Medicine,SUNY Upstate Medical University,Syracuse,NY 13210,United States [2]Department of Gastroenterology,Cleveland Clinic Foundation,Cleveland,OH 44195,United States [3]Department of Gastroenterology,SUNY Upstate Medical University,Syracuse,NY 13210,United States

出  处:《World Journal of Hepatology》2022年第4期670-681,共12页世界肝病学杂志(英文版)(电子版)

摘  要:Hepatic encephalopathy(HE)is a reversible syndrome of impaired brain function and represents one of the many complications of portal hypertension and decompensated liver disease.Although ammonia is clearly implicated in the pathogenesis of HE,the pathogenesis of HE is multifactorial with numerous mechanisms that results in functional impairment of neuronal cells.The initial management of HE focuses on supportive care and stabilization which includes providing appropriate nutritional support.Thereafter,focus should be on identifying and treating the precipitating factors.There are many therapeutic agents available for the management of HE,most of which are directed towards lowering the gut nitrogen load and thus the serum ammonia level.This review aims to provide an update on the conventional and emerging treatment options for HE.

关 键 词:Hepatic encephalopathy LACTULOSE RIFAXIMIN Fecal microbiota transplant Zinc L-ornithine L-aspartate 

分 类 号:R575.3[医药卫生—消化系统]

 

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