Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis  

作　　者：Choul Yong Park Roy S.Chuck 

机构地区：[1]Department of Ophthalmology,Dongguk University,Ilsan Hospital,Goyang,South Korea [2]Department of Ophthalmology and Visual Sciences,Montefiore Medical Center,Albert Einstein College of Medicine,Bronx,NY,USA

出　　处：《Annals of Eye Science》2019年第1期23-28,共6页眼科学年鉴（英文）

基　　金：The study is supported in part by a grant of Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2016R1D1A1B03931724).

摘　　要：In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(www.ncbi.nlm.nih.gov/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking.In conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable.It is necessary to conduct a prospective case-control study for clear guidance for clinicians.

关 键 词：ACANTHAMOEBA KERATITIS COLLAGEN ultraviolet A(UVA) RIBOFLAVIN cross-linking 

分 类 号：R28[医药卫生—中药学]