肺鳞癌患者FGFR1表达与临床病理特征的关系  

Relationship between FGFR1 expression and clinicopathological characteristics in patients with lung squamous cell carcinoma

作　　者：陈杰 吴科芳 CHEN Jie;WU Kefang(Department of Respiratory and Critical Care Medicine,General Hospital of Cixi Third People s Hospital Medical and Health Group,Ningbo 315324,China;Department of Internal Medicine,Changhe Branch of Cixi Third People s Hospital Medical and Health Group,Ningbo 315324,China)

机构地区：[1]慈溪市第三人民医院医疗健康集团(总院)呼吸与危重症医学科,浙江宁波315324 [2]慈溪市第三人民医院医疗健康集团长河分院内科,浙江宁波315324

出　　处：《健康研究》2022年第2期185-188,193,共5页Health Research

基　　金：慈溪市科技计划项目(CN2018023)。

摘　　要：目的探讨成纤维细胞生长因子受体1(FGFR1)表达与肺鳞癌患者临床病理特征之间的关系。方法回顾性分析45例肺鳞癌患者的临床病理资料,采用免疫组织化学法检测肺鳞癌组织与癌旁组织的FGFR l表达水平,分析FGFR l表达与患者临床病理特征及生存期的关系。结果FGFR1在肺鳞癌组织中的阳性表达率(62.22%,28/45)高于在癌旁组织中的阳性表达率(35.56%,16/45),差异有统计学意义(χ^(2)=6.403,P<0.05)。肺鳞癌患者FGFRl阳性表达组和阴性表达组的性别、吸烟史、分化程度、淋巴转移、远处器官转移、TNM分期比较,差异均有统计学意义(P<0.05)。Kaplan-Meier生存曲线显示,FGFR1阴性患者和FGFR1阳性患者的生存时间差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,分化程度、淋巴结转移、远处器官转移、TNM分期、吸烟史、FGFR1阳性是影响肺鳞癌患者预后的独立危险因素(P<0.05)。结论FGFRl阳性是影响肺鳞癌患者预后的独立危险因素,FGFRl表达结果可作为判断肺鳞癌患者病情严重程度和预后的重要参考指标。Objective To investigate the relationship between the expression of fibroblast growth factor receptor 1(FGFR1)and clinicopathological features in patients with lung squamous cell carcinoma.Methods The clinical data of 45 patients with lung squamous cell carcinoma were retrospectively analyzed.The expression levels of FGFRl in lung squamous cell carcinoma tissues and adjacent tissues were detected by immunohistochemistry.And the relationship between FGFRl expression and clinicopathological characteristics and survival time of patients was analyzed.Results The positive expression rate of FGFR1 in lung squamous cell carcinoma tissues(62.22%,28/45)was higher than that in paracancer tissues(35.56%,16/45),and the difference was statistically significant(χ^(2)=6.403,P<0.05).There were statistically significant differences in gender,smoking history,degree of differentiation,lymphatic metastasis,distant organ metastasis and TNM stage between FGFRl positive expression group and negative expression group of patients with lung squamous cell carcinoma(P<0.05).Kaplan-meier survival curve showed a statistically significant difference in survival time between FGFR1-negative and FGFR1-positive patients(P<0.05).Multivariate Logistic regression analysis showed that the degree of differentiation,lymph node metastasis,distant organ metastasis,TNM stage,smoking history and positive FGFR1 expression were independent risk factors affecting the prognosis of lung squamous cell carcinoma patients(P<0.05).Conclusions FGFRl positive was an independent risk factor affecting the prognosis of patients with lung squamous cell carcinoma,and the result of FGFRl expression can be used as an important reference index to judge the severity and prognosis of patients with lung squamous cell carcinoma.

关 键 词：肺鳞癌 成纤维细胞生长因子受体1 生存 TNM分期 

分 类 号：R734.2[医药卫生—肿瘤]