SLP-2在胃癌中的表达及临床意义的Meta分析  

Expression and clinical significance of SLP-2 in gastric cancer:A meta-analysis

作　　者：陶嘉楠 田王钊 安琪 王学红 张盛祺 刘吉 Tao Jianan;Tian Wangzhao;An Qi;Wang Xuehong;Zhang Shengqi;Liu Ji(Graduate School of Qinghai University,Xining 810016,China;Department of Gastroenterology,Affiliated Hospital of Qinghai University,Xining 810000,China)

机构地区：[1]青海大学研究生院,青海西宁810016 [2]青海大学附属医院消化内科,青海西宁810000

出　　处：《临床荟萃》2022年第4期299-304,共6页Clinical Focus

基　　金：青海省科技厅项目青海省消化系统疾病临床医学研究中心(2019-SF-L3)。

摘　　要：目的系统评价SLP-2在胃癌中的表达及其与临床病理参数的相关性。方法计算机检索PubMed、Cochrane Library、EMbase、CBM、CNKI、WanFang Date和VIP数据库,检索国内外关于SLP-2在胃癌中表达的病例-对照研究,检索时限为从建库至2021年11月。由2名研究者独立检索筛选文献、提取资料并评价偏倚风险,用Revman5.3软件进行meta分析。结果最终纳入8个病例-对照研究,共计1079例患者。Meta分析结果显示:SLP-2在胃癌组织中的表达水平明显高于癌旁组织,差异有统计学意义[OR=6.20,95%CI(4.41,8.73),P<0.01];胃癌组织中SLP-2在不同分化程度组[OR=1.41,95%CI(1.04,1.93),P=0.03]、不同浸润深度组[OR=3.84,95%CI(2.70,5.47),P<0.01]、不同淋巴结转移组[OR=2.21,95%CI(1.37,3.56),P=0.001]、不同血行转移组[OR=2.05,95%CI(1.25,3.35),P=0.004]、不同临床分期组[OR=2.79,95%CI(2.08,3.74),P<0.01]中的表达水平差异均有统计学意义。结论SLP-2在胃癌组织和癌旁组织中差异表达,在胃癌组织中的表达水平和临床病理参数相关,提示SLP-2在胃癌的发生中起作用。受到纳入文献数量与质量的限制,上述结果需要更多高质量的研究加以验证。Objective To evaluate the correlation of the expression and pathology parameters of SLP-2 in gastric cancer.Methods Two researchers independently collected and screened case-control studies regarding SLP-2 expression in gastric cancer in domestic and foreign databases as PubMed,Cochrane Library,EMbase,CBM,CNKI,WanFang Date and VIP databases,the construction time was until November 2021;they assessed the risk of bias for these data and used Revman5.3 software for a meta-analysis.Results Eligible 8 case-control studies were included,with a total of 1079 patients.Meta-analysis showed that the expression level of SLP-2 in gastric cancer tissues was significantly higher than that in adjacent tissues[OR=6.20,95%CI(4.41,8.73),P<0.01].In gastric cancer tissues,the expression level of SLP-2 in groups with different degrees of differentiation[OR=1.41,95%CI(1.04,1.93),P=0.03],groups with different depth of invasion[OR=3.84,95%CI(2.70,5.47),P<0.01]and groups with different lymph node Metastasis[OR=2.21,95%CI(1.37,3.56),P=0.001],groups with different blood Metastasis[OR=2.05,95%CI(1.25,3.35),P=0.004],groups with different clinical stage[OR=2.79,95%CI(2.08,3.74),P<0.01]was found had statistical significance.Conclusion There are significant difference in SlP-2 expression between gastric cancer tissues and adjacent tissues,which is correlated with clinicopathological parameters,suggesting that SLP-2 plays a role in gastric cancer incidence.Due to the limited quantity and quality of the above literatures,the conclusions should be verified by more high-quality studies.

关 键 词：胃肿瘤 stomatin样蛋白-2 META分析 

分 类 号：R735.2[医药卫生—肿瘤]