人体铁代谢及其调控因素  

Iron metabolism in human body and its regulatory factors

作　　者：陈春梅 葛品[1] 郭翀[1] CHEN Chun-mei;GE Pin;GUO Chong(Department of Child Healthcare, the Affiliated Hospital of Fujian Medical University, Fujian Maternity and Child Health Hospital,Fuzhou 350005,China)

机构地区：[1]福建省妇幼保健院福建医科大学附属医院儿童保健科,福建福州350005

出　　处：《基础医学与临床》2022年第5期818-823,共6页Basic and Clinical Medicine

基　　金：福建医科大学启航基金(2018QH1189);福建省卫生健康青年科研课题(2019-2-13)。

摘　　要：本文从铁的吸收、转运、利用、储存过程阐述人体铁代谢的分子学机制,着重讨论铁代谢过程中的关键蛋白及其相关的调控因素,明确该机制能期望为更早期、更精准的铁稳态失衡标志物的发现提供新思路,并为未来的靶向治疗提供切入点。This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors.Based on these results of research it might be able to provide some new strategies to find potential biomarkers of iron metabolism to support early and correct diagnosis.What's more,a clear mechanism may also provide a breakthrough point for the targeted treatment of iron metabolism disorders in future.

关 键 词：铁代谢 二价金属转运蛋白1(DMT1) 铁转运蛋白1(FPN1) 铁调素 

分 类 号：R153.2[医药卫生—营养与食品卫生学]