三叶青化学成分及其抗肿瘤作用研究进展  

Chemical Compositions and Anti-tumor Effect of Tetrastigma hemsleyanum:A Review

作　　者：刘俊秋 高语枫 郑佳怡 周瑜城 施广义 张轲杰 刘娜[2] 开国银 LIU Jun-qiu;GAO Yu-feng;ZHENG Jia-yi;ZHOU Yu-cheng;SHI Guang-yi;ZHANG Ke-jie;LIU Na;KAI Guo-yin(School of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 311402,China;Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]浙江中医药大学药学院,杭州311402 [2]重庆市中医院,重庆400021

出　　处：《中国实验方剂学杂志》2022年第9期233-241,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：浙江省农业新品种选育重大科技专项(2021C02074);浙江省“万人计划”科技创新领军人才项目(2018R52050);浙江省中医药科技计划项目(2020ZQ014,2021ZA043)。

摘　　要：因肿瘤细胞具有无限增殖、强迁移性及失去接触抑制等特点,肿瘤已成为最难以治愈的顽固性疾病。目前,肿瘤主要通过手术切除、放化疗、靶向、免疫等方式进行治疗,这些方法虽然在一定程度上可以抑制或杀死肿瘤,但仍无法避免治疗导致的不良反应和耐药性问题等。经过数千年临床实践的中医药,在防治肿瘤方面表现出疗效好、不良反应小、可显著改善患者生存质量等优点,这为肿瘤的防治提供了新思路。三叶青为我国特有珍稀植物,具有清热解毒、消肿止痛、化痰散结等功效,已被2015年版《浙江省中药炮制规范》收录。据报道,三叶青化学成分主要包括黄酮类、多糖类、酚酸类、萜类、甾体类、挥发油类、生物碱类等;其可通过多种途径发挥广谱抗肿瘤作用,如抑制肿瘤细胞增殖、迁移、侵袭,诱导肿瘤细胞凋亡,抑制肿瘤细胞血管形成,逆转肿瘤细胞多药耐药性及调节机体自身免疫等。在查阅国内外相关文献基础上,笔者拟对三叶青的化学成分及抗肿瘤研究进行系统梳理,以期为三叶青多成分、多途径、多靶点的抗肿瘤协同调控作用研究提供新思路,并为其抗肿瘤新药研发及临床应用提供理论依据。Due to the infinite proliferation,strong migration and loss of contact inhibition of tumor cells,tumor has become the most intractable diseases to be cured in the world.At present,the main treatments of tumor diseases are surgical resection,radiotherapy,chemotherapy,targeted-therapy and immunotherapy.Although these measures can inhibit or kill the tumor to a certain extent,they still cannot avoid adverse reactions and drug resistance.After thousands of years of clinical practice,traditional Chinese medicine(TCM)has the characteristics of good curative effect,few adverse reactions and significantly improving the quality of life in patients,which provides new ideas for the prevention and treatment of tumors.As an endemic and rare plant in China,Tetrastigma hemsleyanum has been listed in the 2015 edition of Zhejiang Provincial Processing Specification of TCM with the effects of heat-clearing and detoxification,detumescence and analgesia,dissipating phlegm and resolving masses.It has been reported that the chemical constituents of T.hemsleyanum are mainly flavonoids,polysaccharides,phenolic acids,terpenoids,steroids,volatile oils,alkaloids and so on.It can exert a broad spectrum of anti-tumor effects through various ways such as inhibiting proliferation,migration and invasion of tumor cells,inducing apoptosis of tumor cells,inhibiting angiogenesis of tumor cells,reversing multidrug resistance of tumor cells and regulating body autoimmunity.On the basis of reviewing relevant literature at home and abroad,this paper intends to systematically sort out the chemical and anti-tumor research of T.hemsleyanum,and in order to provide a new idea for its synergistic anti-tumor effect of multicomponent,multi-pathway and multi-target,and finally provide theoretical basis for the research and development and clinical application of new anti-tumor drugs of T.hemsleyanum.

关 键 词：三叶青 化学成分 抗肿瘤 中医药(TCM) 作用机制 新药研发 药理作用 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学]