蓝光联合茵栀黄口服液治疗葡萄糖-6-磷酸脱氢酶缺乏症新生儿黄疸的多中心观察性研究  

A multicenter study on the efficacy of Yinzhihuang oral liquid for the treatment of neonatal jaundice in G6PD deficiency term infants

作　　者：唐丽君[1] 黄为民[1] 崔其亮[2] 邱国莹[2] 杨传忠[3] 叶素芬[3] 钟丹妮 陈虹 韦秋芬[5] 许靖[5] TANG Lijun;HUANG Weimin;CUI Qiliang;QIU Guoying;YANG Chuanzhong;YE Sufen;ZHONG Danni;CHEN Hong;WEI Qiufen;XU Jing(Department of Neonatology,The South Hospital of Southern Medical University,Guangdong,Guangzhou 510515,China;Department of Neonatology,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong,Guangzhou 510150,China;Department of Neonatology,Shenzhen Maternal and Child Health Hospital,Shenzhen 518028,China;Department of Neonatology,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China;Department of Neonatology,The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530000,China)

机构地区：[1]南方医科大学南方医院新生儿科,广东广州510515 [2]广州医科大学第三附属医院新生儿科,广东广州510150 [3]深圳市妇幼保健院新生儿科,广东深圳518028 [4]广西医科大学附属第一医院新生儿科,广西南宁530021 [5]广西壮族自治区妇幼保健院新生儿科,广西南宁530000

出　　处：《现代医学与健康研究电子杂志》2022年第6期67-69,共3页Modern Medicine and Health Research

基　　金：广东省自然科学基金项目(编号:2018A0303130288)。

摘　　要：目的通过观察茵栀黄口服液对葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症足月新生儿经皮测胆红素的影响及不良反应,评价其有效性及安全性。方法选择广东广西5家三甲医院收治的G6PD缺乏症足月新生儿,经临床确诊为新生儿高间接胆红素血症,根据是否口服茵栀黄口服液分为单纯蓝光治疗组(n=189)和蓝光联合茵栀黄口服液组(n=210)。收集两组患儿的一般情况,比较观察前、茵栀黄治疗72 h经皮测胆红素水平、经皮测胆红素水平的下降率及总光疗时间。观察两组患儿的不良反应发生率。结果与观察前比较,治疗72 h单纯蓝光治疗组和蓝光联合茵栀黄口服液组经皮测胆红素水平均降低,两组经皮测胆红素水平下降率比较差异无统计学差异(P>0.05);蓝光联合茵栀黄口服液组光疗时间短于单纯蓝光治疗组(P<0.05);蓝光联合茵栀黄口服液组有29.52%的患儿出现大便次数增加(>5次/d),该比率明显高于光疗组(P<0.05)。结论蓝光联合茵栀黄口服液应用于G6PD缺乏症足月新生儿的黄疸治疗可缩短光疗时间,治疗过程中可能出现轻微腹泻,尚未发现其它严重不良事件。Objective To observe the effect and adverse reactions of Yinzhihuang oral liquid on percutaneous bilirubin test of fullterm newborns with G6PD enzyme activity deficiency,and to evaluate its therapeutic effect and safety.Methods Full term neonates with G6PD deficiency were selected from 5 hospitals in Guangdong and Guangxi.The bilirubin level at admission met the phototherapy standard of the American Academy of Pediatrics.According to the oral administration of yinzhihuang,participants were divided into 2 groups,namely phototherapy group(n=189);yinzhihuang oral liquid combined with phototherapy group(n=210).The Yinzhihuang oral liquid combined with phototherapy group was given Yinzhihuang Oral Liquid 3 mL/time,3 times/d,and lasted for 3 days.The general data of the infants in each group were recorded,and the decrease rate of bilirubin level and the difference of phototherapy time between groups were compared.Results Yinzhihuang oral liquid combined with phototherapy group and simple phototherapy group can significantly reduce the level of transcutaneous bilirubin,and there is no significant difference between the two groups(P>0.05),however,Yin zhi huang oral liquid combined with light therapy can reduce the phototherapy time,the difference was statistically significant(P<0.05).The rate of defecation more than 5 times a day in Yinzhihuang oral liquid combined with phototherapy group was 29.52%,significantly higher than phototherapy group,the difference was statistically significant(P<0.05).Conclusion Yinzhihuang oral liquid combined with phototherapy could treat neonatal jaundice with G6PD deficiency,and could shorten the phototherapy time.The main adverse effect of Yinzhihuang oral liquid was the increase of stool.No other adverse events were found.

关 键 词：茵栀黄口服液 葡萄糖-6-磷酸脱氢酶缺乏症 新生儿黄疸 

分 类 号：R722.1[医药卫生—儿科]