经支气管镜高频电灼联合冷冻及氩离子凝固术在中央型肺癌致气道狭窄中的疗效评价  

Efficacy Evaluation of Bronchoscopic High-frequency Electrocautery Combined with Cryotherapy and Argon Plasma Coagulation in Airway Stenosis Caused by Central Lung Cancer

作　　者：褚叶 梁小红 沈王丰 严正平 CHU Ye;LIANG Xiaohong;SHEN Wangfeng;YAN Zhengping(Zhangjiagang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Zhangjiagang 215600,China;不详)

机构地区：[1]南京中医药大学张家港附属医院,江苏张家港215600

出　　处：《中国医学创新》2022年第13期7-11,共5页Medical Innovation of China

基　　金：张家港市卫生青年科技项目(ZJGQNKJ202034)。

摘　　要：目的:探讨经支气管镜高频电灼联合冷冻及氩离子凝固术(三联疗法)治疗中央型肺癌致气道狭窄的临床效果及安全性。方法:将2018年1月-2020年12月南京中医药大学张家港附属医院收治的96例中央型肺癌致气道狭窄患者依据治疗方式不同分为观察组和对照组,每组48例。观察组行三联疗法,对照组行经支气管镜高频电灼+冷冻。比较两组一般资料,气道狭窄再通效果,术后1个月第一秒用力呼气容积占预计值的百分比(FEV_(1)%pred)、第一秒用力呼气量占用力肺活量的百分比(FEV_(1)/FVC%)、呼气峰值流速(PEF)、气促评分及术后并发症发生率。结果:观察组气管狭窄再通总有效率为89.6%,高于对照组的72.9%(P<0.05)。术后1个月,两组肺功能指标均高于术前,气促评分均低于术前,且观察组均优于对照组,差异均有统计学意义(P<0.01)。观察组术后并发症发生率为10.4%,低于对照组的25.0%,但差异无统计学意义(P>0.05)。结论:三联疗法能有效治疗中央型肺癌致气管狭窄,改善肺功能,有广泛的临床应用价值。Objective:To investigate the clinical efficacy and safety of bronchoscopic high-frequency electrocautery combined with cryotherapy and argon plasma coagulation(triple therapy)in airway stenosis caused by central lung cancer.Method:A total of 96 patients with airway stenosis caused by central lung cancer treated in Zhangjiagang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2018 to December 2020 were divided into the observation group and the control group by different treatment,48 cases in each group.The observation group was treated with triple therapy,while the control group was treated with bronchoscopic high-frequency electrocautery and cryotherapy.The general data,effect of recalculation of airway stenosis,the percentage of forced expiratory volume in one second to predict(FEV_(1)% pred),the percentage of forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC%),peak respiratory lapse(PEF)before and 1 month after surgery and incidence of postoperative complications of two groups were compared.Result:The total effective rate of the observation group was 89.6%,which was significantly higher than 72.9% of the control group(P<0.05).1 month after surgery,the lung function indexes in two groups were higher than those before surgery,and the scores of shortness of breath were lower than those before surgery,and the observation group were better than those of the control group,the differences were statistically significant(P<0.01).The incidence of complications of the observation group was 10.4%,which was lower than 25.0% in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Triple therapy can effectively treat airway stenosis caused by central lung cancer,improve patients’lung function,it has a wide range of clinical application.

关 键 词：支气管镜 高频电灼 冷冻 氩离子凝固术 中央型肺癌 气道狭窄 

分 类 号：R734.2[医药卫生—肿瘤]