奥替溴铵与匹维溴铵对腹泻型肠易激综合征患者症状改善及SF-36、SAS、SDS评分的影响  

Effect of Otionium Bromide and Piveronium Bromide on Symptom Improvement and SF-36,SAS and SDS Scores in Patients with Diarrhea-type Irritable Bowel Syndrome

作　　者：张璐 ZHANG Lu(Chaoyang Central Hospital,Liaoning Province,Chaoyang 122000,China)

机构地区：[1]辽宁省朝阳市中心医院,辽宁朝阳122000

出　　处：《中国医学创新》2022年第13期54-57,共4页Medical Innovation of China

摘　　要：目的:研究奥替溴铵与匹维溴铵对腹泻型肠易激综合征患者症状改善及SF-36、SAS、SDS评分的影响。方法:选取2018年2月-2020年10月朝阳市中心医院收治的85例腹泻型肠易激综合征患者。按照随机数字表法将患者分为观察组(n=42)和对照组(n=43)。对照组采用奥替溴铵治疗,观察组则采用匹维溴铵治疗。比较两组症状改善效果、生活质量(SF-36)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分及不良反应发生情况。结果:治疗后,两组腹痛、腹胀、腹泻、SAS、SDS评分均低于治疗前,各维度SF-36评分均高于治疗前,差异均有统计学意义(P<0.05)。治疗后,两组腹痛、腹胀、腹泻、SAS、SDS、各维度SF-36评分比较,差异均无统计学意义(P>0.05)。两组口干舌燥、头晕、腹部不适、恶心呕吐发生率比较,差异均无统计学意义(P>0.05)。结论:奥替溴铵与匹维溴铵在治疗腹泻型肠易激综合征患者中,均可有效改善患者症状、生活质量及心理状态,且两种药物的改善效果相当,在临床实际工作中可根据具体情况选用。Objective:To analyze the effect of Otionium Bromide and Piveronium Bromide on symptom improvement and SF-36,SAS and SDS scores in patients with diarrhea-type irritable bowel syndrome.Method:A total of 85 patients with diarrhea-type irritable bowel syndrome admitted to Chaoyang Central Hospital from February 2018 to October 2020 were selected,they were divided into observation group(n=42)and control group(n=43)according to random number table method.The control group was treated with Otionium Bromide,and the observation group was treated with Piveronium Bromide.Symptom improvement,quality of life(SF-36),self-rating anxiety scale(SAS),self-rating depression scale(SDS)scores and the incidence of adverse reactions were compared between two groups.Result:After treatment,the scores of abdominal pain,abdominal distension,diarrhea,SAS and SDS in both groups were lower than those before treatment,and the SF-36 scores of all dimensions in both groups were higher than those before treatment,the differences were statistically significant(P<0.05).After treatment,there were no significant differences in abdominal pain,abdominal distension,diarrhea,SAS,SDS and SF-36 scores of all dimensions between two groups(P>0.05).There were no significant differences in the incidences of dry mouth,dizziness,abdominal discomfort,nausea and vomiting between two groups(P>0.05).Conclusion:Otionium Bromide and Piveronium Bromide can effectively improve the symptoms,quality of life and psychological state of patients with diarrhea-type irritable bowel syndrome,and the improvement effect of the two drugs is similar,so they can be selected according to the specific situation in clinical practice.

关 键 词：腹泻型肠易激综合征 奥替溴铵 匹维溴铵 

分 类 号：R574.4[医药卫生—消化系统]