熊果酸-茶氨酸共无定型复合物的制备和水溶性测定  

The Preparation of Ursolic Acid and Theanine Co-amorphous Complex and Its Water Solubility

作　　者：杨仲平 吴琦 杨雅琴 洪燕萍[1,2] YANG Zhongping;WU Qi;YANG Yaqin;HONG Yanping(College of Life science,Longyan University,Longyan Fujian 364000,China;Fujian Provincial Key Laboratory for Biotechnology&Preventive Veterinary Medicine,Longyan Fujian 364000,China)

机构地区：[1]龙岩学院生命科学学院,福建龙岩364000 [2]福建省生物技术与预防兽医学重点实验室,福建龙岩364000

出　　处：《莆田学院学报》2022年第2期45-49,共5页Journal of putian University

基　　金：福建省科技计划引导性项目(2019N0020);枇杷种质资源创新与利用福建省高等学校重点实验室(莆田学院)开放课题(2018001);福建省大学生创新训练项目(202011312044)。

摘　　要：通过制备熊果酸-茶氨酸共无定型复合物,提高熊果酸的水溶解度。采用溶剂法和物理研磨法制备不同配比的熊果酸与茶氨酸的无定型复合物,测定熊果酸的水溶解度,筛选出最佳配比和制备工艺,并对复合物进行PXRD和FTIR的检测分析。结果,熊果酸与茶氨酸最优配比为1∶5,溶剂法比物理研磨法制备效果好。经PXRD检测分析可知,共无定型复合物呈非晶型状态,FTIR检测显示熊果酸与茶氨酸间通过氢键结合形成共无定型复合物。结果表明,熊果酸与茶氨酸经过溶剂法制备形成了共无定型复合物,增加了熊果酸的水溶解度。The purpose of this study is to improve the water solubility of ursolic acid by preparing ursolic acid and theanine co-amorphous complex.Uursolic acid and theanine amorphous complex with different proportions is prepared in solvents and by physical grinding respectively.The water solubility of ursolic acid is measured to optimize the preparation conditions,and the PXRD and FTIR spectrums are analyzed.The optimum ratio of ursolic acid and theanine is 1∶5,and the solvent method is better than physical grinding.The PXRD spectrum shows that the ursolic acid-theanine co-amorphous complex is in an amorphous state while the FTIR spectrum indicates that hydrogen bonding is the main force between ursolic acid and theanine.The results show that ursolic acid and theanine co-amorphous complex prepared in solvents improves the water solubility of ursolic adic significantly.

关 键 词：共无定型复合物 熊果酸 茶氨酸 溶解度 溶剂法 物理研磨法 PXRD FTIR 

分 类 号：R284[医药卫生—中药学]