Aurora-A在胃癌组织中的表达及其临床意义  

Expression of Aurora-A in Gastric Cancer and Its Clinical Significance

作　　者：熊诗萌 刘志昌 高成英 董亮 李双明 刘宏斌 XIONG Shimeng;LIU Zhichang;GAO Chengying(The Second Clinical Medical College of Lanzhou University,Gansu 730030,China)

机构地区：[1]兰州大学第二临床医学院,730030 [2]中国人民解放军联勤保障部队第九四〇医院,兰州730050 [3]甘肃省干细胞与基因药物重点实验室,兰州730050 [4]甘肃中医药大学临床医学院,兰州730000

出　　处：《医学研究杂志》2022年第4期36-40,共5页Journal of Medical Research

基　　金：国家科技惠民计划项目(2012GS620101)。

摘　　要：目的研究Aurora-A在胃癌组织中的表达情况,并探讨其临床意义。方法回顾性收集中国人民解放军联勤保障部队第九四〇医院普外科收住的86例胃癌患者的组织蜡块及临床病理资料,利用免疫组化染色方法检测Aurora-A在胃癌组织及配对癌旁组织的表达情况,分析胃癌组织中Aurora-A的表达水平及其与患者临床病理特征和预后的相关性。结果Aurora-A主要定位于细胞质,Aurora-A在胃癌组织过表达,且与肿瘤病理类型、分化程度、肿瘤最大直径、浸润深度、TNM分期、淋巴结有无转移、脉管有无侵犯、神经有无侵犯之间密切相关(P<0.05);多因素COX回归分析表明,脉管侵犯和Aurora-A蛋白表达可作为胃癌患者总体生存的独立相关危险因素;Kaplan-Meier生存分析结果显示Aurora-A蛋白低表达的胃癌患者比Aurora-A蛋白过表达的胃癌患者总体生存时间更长(P<0.05)。结论Aurora-A在胃癌组织过表达,与胃癌的病理特征密切相关,并且与患者的不良预后显著相关。Objective To explore the expression of Aurora-A in gastric cancer tissues and its clinical significance.Methods A retrospective collection of tissue wax blocks and clinicopathological data of 86 gastric cancer patients admitted to the Department of General Surgery of the 940th Hospital of the PLA Joint Logistic Support Force was performed.The expression level of Aurora-A were detected by immunohistochemical staining method and the relationship between the expression level of Aurora-A and the clinical pathology and prognosis of patients was analyzed.Results Aurora-A was mainly located in the cytoplasm.Aurora-A was overexpressed in gastric cancer tissues,and was related to tumor pathological type,degree of differentiation,tumor maximum diameter,depth of invasion,TNM stage,lymph node metastasis,vascular invasion,and nerve invasion(P<0.05).Multivariate COX regression analysis showed that vascular invasion and Aurora-A protein expression can be used as independent related risk factors for the overall survival of gastric cancer patients.Kaplan-Meier survival analysis results showed that gastric cancer patients with low expression of Aurora-A protein had a longer overall survival time than gastric cancer patients with overexpression of Aurora-A protein(P<0.05).Conclusion Aurora-A is overexpressed in gastric cancer tissues and is closely related to the pathological features of gastric cancer.It is significantly related to the poor prognosis of gastric cancer patients.

关 键 词：胃癌 AURORA-A 临床病理特征 预后 

分 类 号：R4[医药卫生—临床医学] R6