纤维蛋白原与白蛋白比值与颈动脉狭窄的相关性  

Correlation between Fibrinogen Albumin Ratio and Carotid Stenosis

作　　者：宫艺嘉 朱迎慧[1] 赵源征[1] 晁志文[1] 何远宏[1] GONG Yijia;ZHU Yinghui;ZHAO Yuanzheng(Department of Neurology,No.5 Affiliated Hospital of Zhengzhou University,Henan 450052,China)

机构地区：[1]郑州大学第五附属医院神经内一科,450052

出　　处：《医学研究杂志》2022年第4期59-62,共4页Journal of Medical Research

基　　金：河南省医学科技攻关联合共建项目(LHGJ20200475)。

摘　　要：目的探讨纤维蛋白原与白蛋白比值(fibrinogen to albumin ratio,FAR)与动脉粥样硬化型脑梗死患者颈动脉狭窄的相关性。方法回顾性分析2020年1月~2021年6月郑州大学第五附属医院收治的动脉粥样硬化型脑梗死患者共251例,根据颈动脉超声结果将患者分为轻度狭窄组108例,中-重度狭窄组143例,分析两组患者FAR及其他临床及检验资料的差异,使用多因素Logistic回归分析颈动脉中-重度狭窄的危险因素,用ROC曲线评估预测价值。结果患者年龄、Hcy、尿酸、FAR水平两组比较,差异有统计学意义(P分别为0.004、0.000、0.011、0.000)。多因素Logistic回归显示,Hcy(OR=1.049,95%CI:1.007~1.092,P=0.022)、尿酸(OR=1.005,95%CI:1.001~1.009,P=0.013)、FAR(OR=1.045,95%CI:1.028~1.063,P<0.001),为动脉粥样硬化型脑梗死患者颈动脉中-重度狭窄的独立危险因素。FAR预测颈动脉中-重度狭窄的ROC曲线下面积为0.744(95%CI:0.684~0.805,P<0.001)。结论FAR与动脉粥样硬化型脑梗死患者颈动脉狭窄程度相关,可以作为临床帮助预测动脉粥样硬化型脑梗死患者颈动脉狭窄的生化指标,还可帮助临床医生在面对动脉粥样硬化型脑梗死患者时制定更合理的诊疗方案。Objective To investigate the correlation between fibrinogen to albumin ratio(FAR)and carotid stenosis in patients with atherosclerotic cerebral infarction.Methods A total of 251 patients with atherosclerotic cerebral infarction treated in the No.5 Affiliated Hospital of Zhengzhou University from January 2020 to June 2021 were analyzed retrospectively.According to the results of carotid ultrasound,the patients were divided into 108 cases in mild stenosis group and 143 cases in moderate-severe stenosis group.The differences of FAR and other clinical and test data between the two groups were analyzed.The risk factors of moderate-severe carotid stenosis were analyzed by multivariate Logistic regression,and the predictive value was evaluated by ROC curve.Results There were significant differences in age,Hcy,uric acid and FAR between the two groups(P=0.004,P<0.001,P=0.011,P<0.001).Multivariate Logistic regression showed that Hcy(OR=1.049,95%CI:1.007-1.092,P=0.022),uric acid(OR=1.005,95%CI:1.001-1.009,P=0.013)and FAR(OR=1.045,95%CI:1.028-1.063,P<0.001)were independent risk factors for moderate-severe carotid stenosis in patients with atherosclerotic cerebral infarction.FAR predicted that the area under the ROC curve of moderate-severe carotid stenosis was 0.744(95%CI:0.684-0.805,P<0.001).Conclusion FAR is related to the degree of carotid stenosis in patients with atherosclerotic cerebral infarction.It can be used as a biochemical index to predict carotid stenosis in patients with atherosclerotic cerebral infarction.It can also help clinicians make more reasonable diagnosis and treatment plans in the face of patients with atherosclerotic cerebral infarction.

关 键 词：纤维蛋白原 白蛋白 颈动脉狭窄 动脉粥样硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]