局部中晚期喉癌术后辅助放疗短期疗效及影响因素分析  

Short Term Efficacy and Impact of Adjuvant Radiotherapy in Patients with Locally Advanced Laryngeal Cancer

作　　者：李冬雷[1] 肖跃华[2] 王永宝[2] 张旭宇[1] LI Donglei;XIAO Yuehua;WANG Yongbao(Department of Oncology,Baoding Second Central Hospital,Hebei 072050,China)

机构地区：[1]保定市第二中心医院肿瘤科,072750 [2]保定市第二中心医院耳鼻喉科,072750

出　　处：《医学研究杂志》2022年第4期63-67,共5页Journal of Medical Research

基　　金：河北省2019年度医学科学研究课题计划(20191224)。

摘　　要：目的探寻局部中晚期喉癌术后辅助放疗短期疗效及影响因素分析。方法回顾性分析保定市第二中心医院2019年11月~2020年12月收治的80例局部中晚期喉癌患者的临床资料,采用单因素Logistic回归与多元回归模型分析影响中晚期喉癌患者术后辅助放疗疗效及预后的高危因素。结果入组80例中晚期喉癌患者,均全部完成随访,完全缓解9例,部分缓解26例,疾病稳定20例,疾病进展25例,客观缓解率为43.75%,疾病控制率为68.75%。死亡44例(55.00%),纳为死亡组;存活36例(45.00%),纳为存活组;死亡组患者年龄(≥60岁)、有淋巴结转移、临床分期为Ⅳ期、KPS分值≤80分、低分化程度占比均高于存活组,肿瘤标志物水平中SCC-Ag、CEA、CYFRA21-1水平均较存活组高(P<0.05);年龄(≥60岁)、有淋巴结转移、临床分期为Ⅳ期、低分化程度均是影响中晚期喉癌患者术后辅助放疗短期疗效及预后的危险因素(P<0.05)。结论局部中晚期喉癌患者术后辅助放疗疗效及预后情况与患者年龄、淋巴结转移、临床分期、分化程度密切相关。Objective To explore the short-term efficacy and influence factors of adjuvant radiotherapy after surgery for locally middle advanced laryngeal cancer.Methods We retrospectively analyzed the clinical data of 80 patients with locally advanced laryngeal cancer treated in our hospital between November 2019 and December 2020.Univariate Logistic regression and multiple regression models were used to analyze the high-risk factors affecting the efficacy and prognosis of postoperative adjuvant radiotherapy in patients with advanced laryngeal cancer.Results Eighty patients with advanced stage laryngeal cancer were enrolled,all of whom completed follow-up,with 9 complete responses,26 partial responses,20 stable disease,25 progressive disease.The objective response rate was 43.75%.Disease control rate was 68.75%.44 patients(55.00%)diedin the death group,and 36 patients(45.00%)survived in the survival group.Compared with the surviving group,the patients in the death group were older(≥60 years old),and had lymph node metastasis,clinical stageⅣ,KPS score≤80 points,and low differentiated degree,and SCC Ag,CEA,and CYFRA21-1 levels in tumor marker levels were higher(P<0.05).Age(≥60 years old),lymph node metastasis,clinical stageⅣ,and poor differentiation are risk factors that affect the short-term efficacy and prognosis of postoperative adjuvant radiotherapy in patients with advanced laryngeal cancer(P<0.05).Conclusion The efficacy and prognosis of postoperative adjuvant radiotherapy in patients with locally advanced stage laryngeal cancer are closely related to patient age,lymph node metastasis,clinical stage,and differentiation grade.

关 键 词：喉癌 中晚期 肿瘤分期 淋巴结转移 肿瘤标志物 

分 类 号：R739.65[医药卫生—肿瘤]