克罗恩病小肠CT造影活动度分级与粪便乳铁蛋白相关性的研究  

Activity Grading of CT Enterography are well Correlated with Fecal Lactoferrin of Crohn’s Disease

作　　者：陆瑜 蔡瑾 张蓓[2] 陈憩[2] 黄英 栾震 李君荣 LU Yu;CAI Jin;ZHANG Bei(Department of Radiology,Minhang Shanghai Hospital,Gubei Branch Hospital,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200336,P.R.China)

机构地区：[1]民航上海医院放射科,上海交通大学医学院附属瑞金医院古北分院放射科,上海200336 [2]民航上海医院放射科,上海交通大学医学院附属瑞金医院古北分院消化科,上海200336 [3]上海交通大学医学院附属瑞金医院放射科,200021 [4]江苏大学医学院流行病与卫生统计学教研室,镇江212013

出　　处：《临床放射学杂志》2022年第3期509-513,共5页Journal of Clinical Radiology

基　　金：上海市长宁区科委重点项目(编号:CNKW2017Z06)。

摘　　要：目的探讨克罗恩病(CD)的小肠CT造影(CTE)评分、活动度分级与粪便乳铁蛋白(FL)的相关性。方法搜集CD患者39例,测量并分析患者的FL、CTE影像学相关数据(肠壁厚度、强化方式、动脉期CT值、静脉期CT值、CTE评分分值、CTE活动度分级)。分析FL与CTE评分、强化方式及活动度分级的相关性。结果39例CD患者的CTE评分显示1例为轻度活动,14例为中度活动,24例为重度活动,FL平均值为(26.15±6.56)×10^(3)μg/g。Spearman相关性分析法示FL与CTE活动度分级、CTE分值、CTE的强化方式呈中度相关(P<0.001,r_(s)值分别为0.672、0.582、0.662)。结论CD患者的FL与其CTE活动度分级呈中度相关,或可为临床诊疗及随访CD提供更多信息。Objective To assess the correlation between score,activity grading incomputed tomography enterography(CTE)and fecal lactoferrin(FL)of Crohn’s disease(CD).Methods Thirty-nine CD patients who underwent CTE and FL test fromSeptember of 2019 to December of 2020 were included in this study.The FL and CTE findings,such as bowelwall thickness,enhancement,CT values of arterial phase and venous phase after intravenous injection of Iobitridol,CTE score,activity grading in CTE of CD were assessed.The correlation between FL and the score,enhancement,activity grading in CTE of CD were analyzed by using Spearman’s rank correlation.Results CTE findings showed 1 mild activity,14moderate activity and 24 severe activity cases of the 39 CD patients,FL value was(26.15±6.56)×10^(3)μg/g.Spearman’s rank correlation coefficients showed moderate correlation between FL and activity grading,score,enhancement in CTE of CD;P<0.001,r_(s) were 0.672,0.582 and 0.662,respectively.Conclusion Activity grading in CTE of CD was moderately correlated with FL,could be of great value in guiding clinical follow-up and treatment.

关 键 词：炎症性肠病 克罗恩病 小肠CT造影 活动度分级 粪便乳铁蛋白 

分 类 号：R574[医药卫生—消化系统] R816.5[医药卫生—内科学]