外泌体在精神障碍中的研究进展  

Research advances of exosome in mental disorder

作　　者：邓泓[1,2] 翁赛峥 纪家武[1,2] Deng Hong;Weng Saizheng;Ji Jiawu(Fuzhou neuro-psychiatric hospital affiliated to Fujian Medical University;Department of psychology,Fuzhou neuro-psychiatric hospital,Fuzhou,Fujian,350008,China)

机构地区：[1]福建医科大学附属福建省福州神经精神病医院,福建福州350008 [2]福建省福州神经精神病防治院精神科

出　　处：《齐齐哈尔医学院学报》2022年第3期263-267,共5页Journal of Qiqihar Medical University

摘　　要：外泌体广泛分布于各种体液,是神经元和胶质细胞以及其他器官和细胞间的重要通讯途径,可与血脑屏障双向交流信息,在大脑中参与突触可塑性、神经元应激反应、细胞间通讯和神经发生等过程,与精神疾病的发生发展有密切联系。外泌体可以为精神疾病的诊断和治疗干预提供信息,也可作为运输药物特异性载体或临床药物靶点实现精准治疗,具有临床转化前景。Objective Exosomes are widely distributed in various body fluids.They are an important communication pathway between neurons,glial cells and other organs and cells.They can communicate information with the blood-brain barrier in both directions,and participate in synaptic plasticity and neuronal stress response in the brain,the processes of inter-cellular communication and neurogenesis,they are closely related to the occurrence and development of mental illness.Exosomes can provide information for the diagnosis and therapeutic intervention of mental illness,and can also be used as a drug-specific carrier or clinical drug target to achieve precise treatment,which has clinical transformation prospects.

关 键 词：外泌体 精神障碍 精准医疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]