有效抗癫痫治疗对脑瘫合并癫痫患儿康复的影响  

Effect of effective antiepileptic therapy on rehabilitation of children with cerebral palsy complicated with epilepsy

作　　者：聂克霖 蒋超[1] 代印明 NIE Ke-lin;JIANG Chao;DAI Yin-ming(Department of Neurology,The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院神经内科,郑州450052

出　　处：《医药论坛杂志》2022年第5期32-35,共4页Journal of Medical Forum

摘　　要：目的研究脑瘫合并癫痫患儿采用有效抗癫痫治疗的临床效果。方法对郑州大学第五附属医院2018年12月至2019年12月70例脑瘫伴癫痫患儿进行研究,采用随机数表法分成对照组和观察组各35例。对照组予常规治疗,观察组予有效抗癫痫治疗。比较两组治疗效果、癫痫发作频率、脑瘫儿童综合功能评定表评分、格赛尔发育量表(Gesell)评分。结果观察组总有效率为91.43%,高于对照组的71.43%(P<0.05);治疗3个月时,两组癫痫发作频率比较,差异无统计学意义(P>0.05);治疗6个月与12个月时,两组发作频率观察组完全控制率为42.86%和48.57%,明显高于对照组的20.00%和25.71%,差异有统计学意义(P<0.05);治疗前两组综合功能评分比较,差异无统计学意义(P>0.05);治疗后两组综合功能评分均高于治疗前,且观察组[(65.17±9.14)分],高于对照组[(55.41±9.98)分],差异有统计学意义(P<0.05);治疗前两组发育商评分比较无统计学意义(P>0.05);治疗后两组发育商评分均高于治疗前,且观察组(91.27±5.40)分,高于对照组的(88.29±5.43)分,差异有统计学意义(P<0.05)。结论有效抗癫痫治疗应用在脑瘫伴癫痫患儿中效果显著,值得推荐。Objective To study the clinical effect of effective antiepileptic therapy in children with cerebral palsy complicated with epilepsy.Methods A total of 70 children with cerebral palsy with epilepsy in our hospital from December 2018 to December 2019 were studied.They were divided into control group and observation group with 35 cases in each group by random number table method.The control group received routine treatment,and the observation group received effective antiepileptic treatment.The therapeutic effect,seizure frequency,Comprehensive Functional Assessment Scale(Gesell)score and Gesell score of children with cerebral palsy were compared between two groups.Results The total effective rate of observation group was 91.43%,higher than that of control group(71.43%),the difference was statistically significant(P<0.05).After 3 months of treatment,there was no significant difference in the frequency of seizures between the two groups(P>0.05).After 6 months and 12 months of treatment,the complete control rate of attack frequency in observation group was 42.86%and 48.57%,which was significantly higher than that in control group(20.00%and 25.71%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the comprehensive functional scores between the two groups(P>0.05).After treatment,the comprehensive functional scores of both groups were higher than before treatment,and the observation group(65.17±9.14)points were higher than the control group(55.41±9.98)points,the difference was statistically significant(P<0.05).There was no significant difference in developmental quotient scores between the two groups before treatment(P>0.05).After treatment,the development quotient scores of both groups were higher than before treatment,and the observation group(91.27±5.40)points were higher than the control group(88.29±5.43)points,the difference was statistically significant(P<0.05).Conclusion Effective antiepileptic therapy in children with cerebral palsy with epilepsy

关 键 词：康复 脑瘫 抗癫痫治疗 癫痫 治疗效果 

分 类 号：R742.1[医药卫生—神经病学与精神病学]