前列腺小细胞癌靶向精准治疗1例报告  

Targeted therapy for small cell carcinoma of prostate:a case report

作　　者：迟辰斐 刘家舟 樊连城 施永恒[2] 忻志祥 潘家骅[1] 沙建军[1] 朱寅杰[1] 薛蔚[1] 董柏君[1] Chi Chenfei;Liu Jiazhou;Fan Liancheng;Shi Yongheng;Xin Zhixiang;Pan Jiahua;Sha Jianjun;Zhu Yinjie;Xue Wei;Dong Baijun(Department of Urology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Pathology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院泌尿科,上海200127 [2]上海交通大学医学院附属仁济医院病理科,上海200127

出　　处：《中华泌尿外科杂志》2022年第4期299-300,共2页Chinese Journal of Urology

摘　　要：患者,68岁。因尿频、尿急、肉眼血尿1个月就诊。初诊PSA 72.72 ng/ml,碱性磷酸酶(ALP)114 U/L。前列腺穿刺活检病理:前列腺小细胞神经内分泌癌。患者即刻接受药物去势治疗基础上的依托泊苷联合顺铂化疗,累计化疗6次。后外周血游离DNA(cfDNA)基因检测结果示CDK4基因扩增1.99倍。化疗后加用哌柏西利治疗。治疗后3、6个月骨扫描检查提示骨转移灶数量持续明显减少,浓聚程度减低;ALP和PSA持续下降。治疗后随访1年,PSA 0.05 ng/ml,ALP 59 U/L,盆腔MRI和全身骨显像检查提示病灶稳定。A patient aged 68 years old presented urinary frequency,urgency,and gross hematuria for 1 month,with initial PSA of 72.72 ng/ml and alkaline phosphatase(ALP)of 114 U/L.Prostate biopsy pathology showed small cell neuroendocrine carcinoma of prostate.The patient was immediately administered 6 cycle of chemotherapy including etoposide and cisplatin combined with medical castration.The CDK4 gene was detected 1.99 times amplification by peripheral blood free DNA(cfDNA)gene analysis.The chemotherapy was followed by parbosini therapy.The number and density of bone metastases continued to decrease significantly by bone scan at 3 and 6 months after treatment,with a continuous decline of ALP and PSA.After 1 year of follow-up,pelvic MRI and bone systemic imaging indicated stable lesions,with PSA of 0.05 ng/ml and ALP of 59 U/L.

关 键 词：前列腺肿瘤 神经内分泌化 精准治疗 

分 类 号：R737.25[医药卫生—肿瘤]