肠道疾病中胆汁酸及其受体对NLRP3炎症小体调控作用的研究进展  

Research Progress in the Regulation of Bile Acids and Bile Acid-activated Receptor on NLRP3 Inflammasome in Intestinal Diseases

作　　者：廖楚瑶 李思奇 张尊建[1] 张培[1] 许风国[1] LIAO Chuyao;LI Siqi;ZHANG Zunjian;ZHANG Pei;XU Fengguo(Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009

出　　处：《药学进展》2022年第3期218-225,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金项目(No.82073812,No.81773861,No.81773682);江苏省杰出青年科学基金(No.BK20180027);中央高校基本科研业务费专项资金(No.2632021PY03)。

摘　　要：胆汁酸作为一种重要的内源性信号分子,参与机体代谢、免疫和炎症等多种生理病理过程,对维持肠道的正常生理功能具有重要作用。核苷酸结合寡聚结构域样受体蛋白3(NLRP3)炎症小体是一种模式识别受体,可通过识别病原体相关分子模式或危险相关分子模式,感知外源性微生物或来自损伤、死亡细胞的内源性危险信号,从而调节肠道免疫进程。研究表明,胆汁酸与NLRP3炎症小体之间存在多种调控模式,共同参与肠道稳态维持和疾病调节。基于国内外现有相关研究综述了肠道疾病中胆汁酸及其受体对NLRP3炎症小体调控作用的研究进展。Bile acids, vital signaling molecules that play important roles in the regulation of metabolism, immunity and inflammation,are closely associated with intestinal homeostasis. NOD-like receptor protein 3(NLRP3) inflammasome is a kind of pattern recognition receptor. It can perceive exogenous microorganisms or endogenous danger signals from damaged or dead cells by recognizing pathogenassociated molecular patterns(PAMPs) or danger-associated molecular patterns(DAMPs), so as to regulate intestinal immune process.Studies have shown that there are multiple regulatory patterns between bile acids and NLRP3 inflammasome, which are involved in the maintenance of intestinal homeostasis and regulation of disease. This review summarizes current research advances at home and abroad in the regulation of bile acids and bile acid-activated receptor on NLRP3 inflammasome in intestinal diseases.

关 键 词：胆汁酸 胆汁酸激活受体 NLRP3炎症小体 肠道损伤 

分 类 号：R574[医药卫生—消化系统]