Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women  

作　　者：Xiaowei Ji Jing Wang Zhuoying Li Qiuming Shen Jiayi Tuo Jinghao Bi Yuting Tan Honglan Li Yongbing Xiang 

机构地区：[1]State Key Laboratory of Oncogene and Related Genes&Department of Epidemiology,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China [2]School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Cancer Biology & Medicine》2022年第3期370-383,共14页癌症生物学与医学（英文版）

基　　金：supported by the National Key Project of Research and Development Program of China(Grant No.2016YFC1302503);the National Key Basic Research Program of China“973 Program”(Grant No.2015CB554000);the State Key Project Specialized for Infectious Diseases of China(Grant Nos.2008ZX10002-015 and 2012ZX10002008-002);the US National Institutes of Health(Grant No.UM1 CA173640).

摘　　要：Objective:This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.Methods:A total of 72,704 Chinese women were followed up from the time of baseline recruitment(1996–2000)to the end of 2016.Dietary fat intake was calculated using a validated food frequency questionnaire.The Cox regression model was used to assess the hazard ratio(HR)and 95%confidence intervals(CI)for dietary fat intake and liver cancer risk.Results:We identified 252 incident liver cancer cases out of 1,267,845 person-years during the overall follow-up time.Null associations,neither in quartiles nor per standard deviation(SD)increment,were detected between liver cancer risk and dietary total fat,fat subtypes and subtype ratios,and food sources.The HR(95%CI)of the 1-SD increment was 1.03(0.90–1.17)for total fat,1.06(0.93–1.20)for saturated fat,1.06(0.93–1.21)for monounsaturated fat,and 1.00(0.89–1.13)for polyunsaturated fat.Similar null associations were observed in stratification analyses according to body mass index and menopausal status.Conclusions:In our prospective cohort study,no significant association was observed in Chinese women between dietary fat and liver cancer risk,and in stratification and sensitivity analyses.

关 键 词：Liver cancer dietary fat prospective cohort Chinese women 

分 类 号：R735.7[医药卫生—肿瘤]