卵巢浆液性肿瘤组织中SIRT1、NAC1、Rap1蛋白表达及意义  

Expression and Significance of SIRT1,NAC1,Rap1 Protein in Ovarian Serous Tumors Tissue

作　　者：张豪[1] 祝参[2] 余筱 ZHANG Hao;ZHU Shen;YU Xiao(Anyang District Hospital,Puyang,455000)

机构地区：[1]河南省濮阳市安阳地区医院,455000 [2]河南省人民医院,450003

出　　处：《实用癌症杂志》2022年第5期732-735,共4页The Practical Journal of Cancer

摘　　要：目的探讨卵巢浆液性肿瘤组织中SIRT1、NAC1、Rap1蛋白的表达及其临床意义。方法选取卵巢浆液性肿瘤患者的肿瘤组织标本100份,选取同期收治的卵巢良性肿瘤患者的肿瘤组织标本100份作为对照。采用SP法检测2组肿瘤组织中SIRT1、NAC1、Rap1蛋白的阳性表达情况,并比较差异。分析卵巢浆液性肿瘤组织SIRT1、NAC1、Rap1蛋白表达与临床病理特征的关系。结果卵巢浆液性肿瘤组织中SIRT1、NAC1、Rap1蛋白阳性表达率分别为65.00%、60.00%、55.00%,高于卵巢良性肿瘤组织的6.00%、20.00%、8.00%(P<0.05)。Ⅲ+Ⅳ期、中低分化、有淋巴结转移的患者肿瘤组织中SIRT1、NAC1、Rap1蛋白阳性表达率较高(P<0.05);Logistic回归分析结果显示,临床分期是卵巢浆液性肿瘤组织SIRT1、NAC1、Rap1蛋白阳性表达的独立影响因素。结论卵巢浆液性肿瘤组织中SIRT1、NAC1、Rap1蛋白存在过表达,且与临床分期密切相关,其可能参与卵巢浆液性肿瘤的进展。Objective To investigate the expression and clinical significance of SIRT1,NaC1 and Rap1 in ovarian serous tumor tissue.Methods 100 samples of ovarian serous tumor tissue were selected,and 100 samples of ovarian benign tumor tissue treated were selected as the control group.The expression levels of SIRT1,NaC1 and Rap1 in the 2 groups were measured by SP method,and the differences between the 2 groups were compared.Results the positive rates of SIRT1,NaC1 and Rap1 were 65.00%,60.00%and 55.00%,respectively,which were higher than those of benign ovarian tumors(6.00%,20.00%and 8.00%,P<0.05);the positive rates of SIRT1,NaC1 and Rap1 were higher in patients with stageⅢ+Ⅳ,middle and low differentiation and lymph node metastasis(P<0.05);the results of logistic multivariate analysis showed that the clinical stage was ovarian plasma Independent risk factors of SIRT1,NaC1 and Rap1 protein expression in liquid tumor tissue.Conclusion SIRT1,NaC1 and Rap1 are overexpressed in ovarian serous tumors,which are closely related to clinical stage and may be involved in the development of ovarian serous tumors.

关 键 词：卵巢浆液性肿瘤 SIRT1 NAC1 Rap1 

分 类 号：R737.31[医药卫生—肿瘤]