血清神经元特异性烯醇化酶、组织多肽抗原、胃泌素释放肽前体对非小细胞肺癌的诊断价值研究  

The Value of Serum NSE,ProGRP and TPA in Non-traumatic Diagnosis of Patients with NSCLC

作　　者：刘颖 任中海[1] 张英丽[1] LIU Ying;REN Zhonghai;ZHANG Yingli(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2022年第5期752-754,757,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:2018131139)。

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者血清神经元特异性烯醇化酶(NSE)、组织多肽抗原(TPA)、胃泌素释放肽前体(ProGRP)在非创伤性诊断中的价值。方法收集经病理学检查确诊的74例NSCLC患者(NSCLC组),选择同期体检中心获取的60例健康成年人作为志愿者(对照组);检查二组血清NSE、ProGRP、TPA水平;采用受试者工作曲线分析三项指标单独及联合应用诊断NSCLC的价值。结果NSCLC组患者的血清NSE、ProGRP、TPA水平均高于对照组,均具有统计学差异(P<0.05);血清NSE诊断NSCLC的灵敏度为34.82%、特异度为81.66%、ROC曲线下面积AUC值为0.623;血清ProGRP诊断NSCLC的灵敏度为42.74%、特异度为84.09%、ROC曲线下面积AUC值为0.668;血清TPA诊断NSCLC的灵敏度为51.28%、特异度为89.63%、ROC曲线下面积AUC值为0.704;血清NSE、ProGRP、TPA水平联合诊断NSCLC的灵敏度为93.20%、特异度为83.87%、ROC曲线下面积AUC值为0.879。结论血清NSE、ProGRP、TPA单独应用时诊断NSCLC的灵敏度较低,三项指标联合应用对于可提高真的灵敏度。Objective To investigate the value of serum neuron specific enolase(NSE),tissue polypeptide antigen(TPA),and gastrin releasing peptide precursor(ProGRP)in non-small cell lung cancer(NSCLC)patients in non-invasive diagnosis.Methods 74 patients with NSCLC diagnosed by pathology(NSCLC group)and 60 healthy adults were selected as the control group;serum NSE was examined in both groups.ProGRP,TPA levels;the use of receiver operating curve analysis of the 3 indicators alone and in combination to diagnose the value of NSCLC.Results The serum levels of NSE,ProGRP and TPA in the NSCLC group were significantly higher than those in the control group(P<0.05).The sensitivity of serum NSE for the diagnosis of NSCLC was 34.82%,the specificity was 81.66%,and the area under the ROC curve AUC.The value of serum ProGRP for the diagnosis of NSCLC was 42.74%,the specificity was 84.09%,and the area under the ROC curve was AUC 0.668.The sensitivity of serum TPA for the diagnosis of NSCLC was 51.28%,the specificity was 89.63%,and the area under the ROC curve AUC.The value of 0.704;serum NSE,ProGRP,TPA level combined with diagnosis of NSCLC sensitivity was 93.20%,specificity was 83.87%,and the area under the ROC curve AUC value was 0.879.Conclusion The sensitivity of serum NSE,ProGRP,and TPA for the diagnosis of NSCLC alone is low,and the combination of the three indicators can improve the true sensitivity.

关 键 词：非小细胞肺癌 神经元特异性烯醇化酶 组织多肽抗原 胃泌素释放肽前体 

分 类 号：R734.2[医药卫生—肿瘤]