乌药成分异乌药内酯抗H.pylori及其抗菌谱的筛选  

Screening of the anti-H.pylori and its antibacterial spectrum of isolinderalactone

作　　者：覃春 徐佳音 王雪 管爱星 廖丽娟 黄永毅[2] 黄赞松 Qin Chun;Xu Jiayin;Wang Xue;Guan Aixing;Liao Lijuan;Huang Yongyi;Huang Zansong(Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Research Center for the Prevention and Control of Drug-Resistant Microbial Infection,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院耐药微生物感染防治研究中心,广西百色533000

出　　处：《右江民族医学院学报》2022年第2期155-157,179,共4页Journal of Youjiang Medical University for Nationalities

基　　金：国家自然科学基金项目(32060018)。

摘　　要：目的筛选异乌药内酯的抗菌谱。方法微量稀释法检测异乌药内酯对不同H.pylori菌株及非H.pylori菌株的最小抑菌浓度(MIC)。结果异乌药内酯对敏感和耐药H.pylori菌株的MIC均为8~16μg/ml;异乌药内酯对金黄色葡萄球菌等非H.pylori菌株的MIC均>128μg/ml。结论异乌药内酯对H.pylori有明显的抑制作用,并可专一作用于H.pylori。Objective To screen the antibacterial spectrum of isolinderalactone.Methods The method of microdilution was adopted to detect the minimum inhibitory concentration(MIC)of isolinderalactone against different H.pylori and non-H.pylori strains.Results The MIC of isolinderalactone against sensitive H.pylori and drug-resistant H.pylori strains was all 8~16μg/ml.The MIC of isolinderalactone against staphylococcus aureus and other non-H.pylori strains was all greater than 128μg/ml.Conclusion Isolinderalactone has significant inhibitory effect on H.pylori and the effect was specific.

关 键 词：幽门螺杆菌 异乌药内酯 抗菌谱 

分 类 号：R573[医药卫生—消化系统]