S-腺苷蛋氨酸应用于慢性乙型肝炎合并抑郁患者的效果  

The effect of S-adenosylmethionine in patients with chronic hepatitis B combined with depression

作　　者：陈悠 崔丹桂 CHEN You;CUI Dangui(Xi'an Eighth Hospital,Xi'an 710061,China)

机构地区：[1]西安市第八医院,西安710061 [2]西安市急救中心

出　　处：《国际精神病学杂志》2022年第2期331-334,共4页Journal Of International Psychiatry

摘　　要：目的探讨S-腺苷蛋氨酸辅助治疗慢性乙型肝炎合并抑郁患者的效果。方法选取我科2018年8月~2020年8月收治的93例慢性乙型肝炎合并抑郁患者,随机分两组,对照组46例给予常规治疗,观察组47例增加S-腺苷蛋氨酸辅助治疗,对比两组肝功能指标(治疗前后谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、总胆汁酸(TBA)水平),神经功能(治疗前后血清脑源性神经生长因子(BDNF)、去甲肾上腺素(NE)、5-羟色胺(5-HT)水平),心理状态(治疗前后SDS评分、SAS评分)和不良反应。结果治疗后两组ALT、AST、TBIL、TBA指标和SDS、SAS评分较治疗前降低,观察组低于对照组(P<0.05)。治疗后两组BDNF、NE、5-HT水平较治疗前升高,观察组高于对照组(P<0.05)。观察组不良反应发生率为4.26%,对照组不良反应发生率为2.17%(P>0.05)。结论S-腺苷蛋氨酸辅助治疗慢性乙型肝炎合并抑郁患者的效果满意,肝功能等实验室指标得到改善,心理状态明显好转,安全性好。Objective To explore the effect of S-adenosylmethionine in adjuvant treatment of chronic hepatitis B patients with depression.Methods Ninety-three patients with chronic hepatitis B and depression admitted to our department from August 2018 to August 2020 were selected and randomly divided into two groups.46 cases in the control group were given conventional treatment,and 47 cases in the observation group were treated with adjuvant S-adenosylmethionine,The liver function indicators(allanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),total bile acid(TBA)levels before and after treatment),laboratory indicators(treatment Serum brain-derived nerve growth factor(BDNF),norepinephrine(NE),5-hydroxytryptamine(5-HT)levels before and after),mental state(SDS score,SAS score before and after treatment),and adverse reactions were compared between two group.Results After treatment,the ALT,AST,TBIL,TBA indexes and SDS and SAS scores of the two groups were lower than those before treatment,and the observation group was lower than that of the control group(P<0.05).After treatment,the levels of BDNF,NE and 5-HT in the two groups were higher than before treatment,and the observation group was higher than the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.26%,and the incidence of adverse reactions in the control group was 2.17%(P>0.05).Conclusion The effect of S-adenosylmethionine in adjuvant treatment of patients with chronic hepatitis B combined with depression is satisfactory,liver function and laboratory indicators have been improved,mental state has improved significantly,and the safety factor is high.

关 键 词：S-腺苷蛋氨酸 慢性乙型肝炎 抑郁 

分 类 号：R749.053[医药卫生—神经病学与精神病学]