白蛋白与纤维蛋白原的比值对结直肠癌根治术患者预后的预测价值  

Effect of albumin to fibrinogen ratio on the prognosis of patients undergoing radical resection for colorectal cancer

作　　者：王宏刚[1] 胡浩然 夏勇 周亚星[1] 杨龙 李立军[1] 王勇[1] 姜建国[1] 刘庆宏[1] Wang Honggang;Hu Haoran;Xia Yong;Zhou Yaxing;Yang Long;Li Lijun;Wang Yong;Jiang Jianguo;Liu Qinghong(Department of General Surgery,Taizhou People's Hospital,Taizhou 225300,China;Postgraduate Training Base of Dalian Medical University,Taizhou People's Hospital,Dalian 116044,China;School of Medicine,Nantong University,Nantong 226007,China)

机构地区：[1]泰州市人民医院普通外科,泰州225300 [2]大连医科大学研究生培养基地泰州市人民医院,大连116044 [3]南通大学医学院,南通226007

出　　处：《中华普通外科杂志》2022年第4期241-244,共4页Chinese Journal of General Surgery

摘　　要：目的探讨白蛋白与纤维蛋白原的比值(AFR)对结直肠癌根治术患者预后的预测价值。方法回顾性分析2015年8月至2017年7月在泰州市人民医院普通外科行腹腔镜结直肠癌根治术216例患者的临床病理资料,同时收集术前7 d内患者的血清白蛋白和血浆纤维蛋白原测定结果,通过ROC曲线Youden指数确定AFR最佳界点,采用Kaplan-Meier分析、单因素和多因素COX回归模型分析预后的影响因素。结果术前AFR对腹腔镜结直肠癌根治术患者术后总生存率的最佳界值为9.43。单因素和多因素分析结果显示:年龄≤65岁、TNM分期Ⅰ~Ⅱ期、AFR≥9.43患者有更长的总生存期和无病生存期(均P<0.05)。结论术前AFR水平对腹腔镜结直肠癌根治术患者的术后生存具有良好的预测作用,并且AFR<9.43是术后总生存期和无病生存期的独立危险因素。Objective To investigate the effect of albumin to fibrinogen ratio on the prognosis of patients undergoing radical resection for colorectal cancer.Methods Clinical and pathological data of 216 patients who underwent laparoscopic radical resection of colorectal cancer at the General Surgery Department of Taizhou People's Hospital from Aug 2015 to Jul 2017 were retrospectively analyzed.Albumin and fibrinogen results within 7 days before surgery was collected.The optimal cut-off point of AFR was determined by Youden index of ROC curve.Kaplan-Meier analysis,univariate and multivariate COX regression models were used to analyze the prognostic factors of OS and DFS.Results The best postoperative OS threshold of AFR for patients undergoing laparoscopic radical resection of colorectal cancer was 9.43.Univariate analysis and multivariate COX regression analysis showed that age≤65 years,TNM stageⅠ-Ⅱ,and AFR≥9.43 had better OS and DFS(all P<0.05).Conclusions Preoperative AFR level had a good predictive value on postoperative survival of patients undergoing laparoscopic radical resection of colorectal cancer,and AFR<9.43 was an independent risk factor for postoperative OS and DFS.

关 键 词：结直肠肿瘤 白蛋白 纤维蛋白原 预后 

分 类 号：R735.34[医药卫生—肿瘤]