循环肿瘤细胞预测结直肠癌患者预后的价值  

Study on the prognostic value of circulating tumor cells in colorectal cancer patients

作　　者：于军辉 白艳艳 金岚[3] 姚宏伟[3] 王今[3] 张忠涛[3] 杨盈赤[3] Yu Junhui;Bai Yanyan;Jin Lan;Yao Hongwei;Wang Jin;Zhang Zhongtao;Yang Yingchi(Department of Peritoneal Cancer Surgery,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Geriatrics,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center of Digestive Disease,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京世纪坛医院腹膜肿瘤外科,北京100038 [2]首都医科大学附属北京世纪坛医院老年医学科,北京100038 [3]首都医科大学附属北京友谊医院普通外科,国家消化系统疾病临床医学研究中心,北京100050

出　　处：《中华普通外科杂志》2022年第4期245-249,共5页Chinese Journal of General Surgery

基　　金：国家科技支撑计划资助项目国家科技支撑计划课题(2015BAI13B09);北京世纪坛医院青年基金项目(2020-q17)。

摘　　要：目的探讨循环肿瘤细胞(CTC)对结直肠癌患者预后的预测价值。方法分析181例结直肠癌患者的CTC和临床病理资料,并分析患者的预后。结果181例结直肠癌患者术前和术后CTC阳性率分别为66.3%和65.7%,差异无统计学意义(χ^(2)=0.012,P=0.912);Ⅱ期结直肠癌复发与未复发患者术后CTC阳性率分别为29.2%和8.0%,差异有统计学意义(χ^(2)=4.303,P=0.038);Ⅱ期结直肠癌患者术后CTC阳性和CTC阴性患者无进展生存期分别为28.7个月和34.0个月,差异有统计学意义(χ^(2)=4.096,P=0.043)。结论术后CTC对Ⅱ期结直肠癌患者的预后有预测价值。Objective To explore the prognostic value of circulating tumor cell(CTC)for colorectal cancer.Method We analyze the correlation between CTC and clinicopathological data,survival curve and overall survival.Results The positive rates of preoperative and postoperative CTC in 181 colorectal cancer patients were 66.3%and 65.7%respectively(χ^(2)=0.012,P=0.912).The postoperative CTC positive rates for recurrence and non-recurrence of stageⅡcolorectal cancer were 29.2%and 8.0%,respectively(χ^(2)=4.303,P=0.038).The progress free survuval of CTC-positive and CTC-negative in postoperative stageⅡcolorectal cancer patients were 28.7 months and 34.0 months,respectively(χ^(2)=4.096,P=0.043).Conclusion Postoperative CTC detection has predictive prognostic value for patients with stageⅡcolorectal cancer.

关 键 词：结直肠肿瘤 肿瘤细胞 循环 预后 预测 

分 类 号：R735.34[医药卫生—肿瘤]