D-D二聚体和纤维蛋白原凝血功能指标在卵巢癌患者预后中的价值  

Prognostic value of D-dimer and fibrinogen coagulation indexes in patients with ovarian cancer

作　　者：陈璐[1] 范菽卫 范希景 CHEN Lu;FAN Shu-wei;FAN Xi-jing(Clinical Laboratory,Jinhua Central Hospital,Jinhua,Zhejiang 321000,China)

机构地区：[1]浙江省金华市中心医院检验科,浙江金华321000

出　　处：《中国卫生检验杂志》2022年第6期727-729,734,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探索临床5项凝血功能检测指标在卵巢癌患者预后中的临床价值。方法回顾性分析金华市中心医院检验科2014年6月—2020年12月162例卵巢癌患者的PT、APTT、TT、FIB、D-dimer 5项凝血检测指标,通过SPSS软件进行Cox回归模型预后分析。Graphpad软件进一步绘制凝血指标ROC曲线,根据对卵巢癌患者诊断的约登指数获取D-dimer及FIB最佳临界值,对5项凝血功能指标进行生存分析。结果与122例健康体检者相比,162例卵巢癌患者的PT、APTT、TT、FIB、D-dimer 5项凝血检测指标显著升高;Cox多因素回归分析发现D-dimer(HR=1.215,95%CI:1.001~1.301,P<0.05)及FIB(HR=1.256,95%CI:0.952~1.291,P<0.05)显著上升是影响卵巢癌预后生存的危险因素(P<0.05);D-dimer及FIB对卵巢癌患者诊断的最佳临界值分别是270μg/L和4.1 g/L。并根据此临界值进一步生存分析结果表明,D-dimer和FIB高表达患者的生存期显著低于低表达患者(P<0.05)。结论D-dimer和FIB对卵巢癌预后有一定的临床意义,是其预后的独立影响因素。Objective To explore the clinical value of five coagulation indexes in the prognosis of ovarian cancer patients.Methods PT,APTT,TT,Fib and D-Dimer of 162 patients with ovarian cancer from June 2014 to December 2020 were retrospectively analyzed in the Clinical Laboratory of Jinhua Central Hospital.Cox regression model was used to analyze the prognosis by SPSS software.The ROC curve of coagulation indexes for diagnosis of the ovarian cancer patients was further drawn by Graphpad software,and the optimal critical values of D-dimer and FIB were obtained according to Youden index.Survival analysis was conducted for 5 coagulation indexes.Results Compared with 122 healthy subjects,PT,APTT,TT,Fib and D-dimer were significantly increased in 162 patients with ovarian cancer;Cox multivariate regression analysis showed that the significant increase of D-dimer(HR=1.215,95%CI:1.001-1.301,P<0.05)and FIB(HR=1.256,95%CI:0.952-1.291,P<0.05)were the risk factors affecting the prognosis and survival of ovarian cancer(P<0.05);The optimal critical values of D-dimer and FIB were 4.1 g/L and 270 ug/L for the diagnosis of ovarian cancer patients,respectively.Further survival analysis showed that the survival time of patients with high expression of D-dimer and Fib was significantly lower than that of patients with low expression of D-dimer and Fib(P<0.05).Conclusion D-dimer and Fib have a useful clinical significance and the independent factors on the prognosis of ovarian cancer patients.

关 键 词：卵巢癌 预后 D-D二聚体 纤维蛋白原 

分 类 号：R737[医药卫生—肿瘤]