脑源性神经营养因子与肿瘤的相关性  

Correlation between brain-derived neurotrophic factor and tumor

作　　者：巨春雷 胡昌辰(综述) 陈胜利(审校) JU Chunlei;HU Changchen;CHEN Shengli(Shanxi Medical University,Taiyuan 030000;Department of Neurosurgery,People’s Hospital Affiliated to Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学附属人民医院神经外科,太原030000

出　　处：《临床与病理杂志》2022年第4期969-973,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(30901774);山西省重点研发计划项目(国际合作)(201803D421055)。

摘　　要：近年来,由于肿瘤的发病率和病死率逐渐升高,关于肿瘤病因学的研究也不断深入。脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)作为神经营养因子超家族中的一员,目前已被证明与多种疾病的发生、发展相关,BDNF与酪氨酸激酶受体B(tyrosine kinase B,TrkB)结合后可通过促进肿瘤血管、神经生成,诱导肿瘤细胞上皮间质转换等途径,在肿瘤的转移、侵袭及耐药性的产生中发挥重要作用。In recent years,incidence rate and mortality rate of cancer have been increasing.As a member of the neurotrophic factor superfamily,brain-derived neurotrophic factor(BDNF)has been proved to be associated with the occurrence and development of many diseases,among them,the binding of BDNF with tyrosine kinase B(TrkB)plays a key role in tumor metastasis,invasion,and drug resistance by promoting tumor angiogenesis and neurogenesis,as well as epithelial mesenchymal transition of tumor cells.

关 键 词：脑源性神经营养因子 肿瘤 微RNA 长链非编码RNA 

分 类 号：R730.2[医药卫生—肿瘤]