非洲猪瘟病毒入侵细胞机制的研究进展  

Research Progress on the Mechanism of African Swine Fever Virus Invading Cells

作　　者：彭国瑞[1,2,3] 邹兴启 徐嫄[1] 徐小艾[1] 朱元源 赵启祖[1] 刘业兵[1] PENG Guo-rui;ZOU Xing-qi;XU Yuan;XU Xiao-ai;ZHU Yuan-yuan;ZHAO Qi-zu;LIU Ye-bing(China Institute of Veterinary Drug Control, Beijing 100081, China;College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China)

机构地区：[1]中国兽医药品监察所,北京100081 [2]中国农业大学动物医学院,北京100193 [3]中国科学院微生物研究所,北京100101

出　　处：《中国兽药杂志》2022年第4期71-75,共5页Chinese Journal of Veterinary Drug

基　　金：国家重点研发计划“ASFV适应性免疫应答机制”(2021YFD1800105);中国兽医药品监察所“兽药行业公益性重点专项”(GY202101)。

摘　　要：病毒进入宿主细胞的途径和方式决定了病毒的趋向性和发病机制,病毒感染细胞包括吸附、穿入、脱壳、复制、组装及子代病毒颗粒的释放等步骤,对病毒入侵机制研究可以为开发有针对性的预防策略提供思路。非洲猪瘟病毒作为一种有囊膜双链DNA病毒,其入侵宿主细胞的机制与其他病毒有一定的相似之处,同样也有其特殊性。目前,人们对非洲猪瘟病毒与宿主细胞相互作用,特别是入侵机制的了解仍然非常有限。为此,本文就ASFV入侵细胞的有关研究进展进行了综述,以期为非洲猪瘟病毒致病机制相关研究提供参考。The mechanism of the virus invading the host cells determines the tendency and pathogenesis of the virus.The steps of the virus infecting cells include adsorption,penetration,unpacking,replication,assembly and release of offspring virus particles.The study of the invasion mechanism of the virus can provide ideas for the development of targeted prevention strategies.The mechanism of African swine fever virus invading host cells is similar to other viruses,and it has the particularity as a capsule double-stranded DNA virus.At present,the knowledge of the interaction of the African swine fever virus with the host cells,especially the invasion mechanism,remains very limited.Accordingly,the research progress of ASFV invasion cells is reviewed in this paper.

关 键 词：非洲猪瘟病毒 病毒入侵 巨噬细胞 细胞 内化 

分 类 号：S852.65[农业科学—基础兽医学]