钙蛋白酶系统介导的骨骼肌蛋白降解  

Degradation of skeletal muscle protein mediated by the calpain system

作　　者：林俊 刘鑫 杨飞云[2] 齐仁立[2] LIN Jun;LIU Xin;YANG Feiyun;QI Renli(Chongqing Agricultural School,Jiulongpo Chongqing 401329,China;Chongqing Academy of Animal Science,Rongchang Chongqing 402460,China;Southwest University,College of Animal Science and Technology,Rongchang Chongqing 402460,China;不详)

机构地区：[1]重庆市农业学校,重庆九龙坡401329 [2]重庆市畜牧科学院,重庆荣昌402460 [3]西南大学动物科技学院,重庆荣昌402460

出　　处：《中国饲料》2022年第8期5-8,共4页China Feed

基　　金：重庆市财政资金引导专项项目(20206,21210,21515);重庆市自然科学基金项目(19209)。

摘　　要：钙蛋白酶系统由多种Ca^(2+)激活的钙蛋白酶和钙蛋白酶抑制蛋白组成。钙蛋白酶系统介导的肌原纤维分解是骨骼肌蛋白降解的主要限速步骤,在维持肌肉生理稳态和肌肉完整性方面发挥了重要的作用。本文综述了钙蛋白酶系统的蛋白结构,激活和调控机制,以及日粮营养对钙蛋白酶系统的影响,以期为相关研究提供帮助。As a proteolytic enzyme system,the calpain system could be activated by intracellular Ca^(2+)in different cells.The system composed of a variety of Calpains and Calpastatin,the calpain inhibitor.In the skeletal muscle tissues,myofibril splitting mediated by the calpain system is a main rate-limiting step for muscle protein degradation.Therefore,the system plays an important role in the maintaining for muscle physiological homeostasis and muscle integrity.This paper reviews the understandings about protein structure,regulatory mechanism and the influences of diet nutrition of the calpain system and therefore,to provide helps for the related studies.

关 键 词：钙蛋白酶 蛋白降解 肌原纤维 骨骼肌 营养调控 

分 类 号：S811.2[农业科学—畜牧学]