左侧乳腺癌患者根治术后常规调强计划与电子束适形联合调强计划的剂量比较  

Dosimetric comparison between conventional IMRT and EBCRT combined with IMRT for post-mastectomy left-sided breast cancer patients

作　　者：杨继明 程杭 马敏 张伟超 吴勇 任江平[1] 郭建新[1] Yang Jiming;Cheng Hang;Ma Min;Zhang Weichao;Wu Yong;Ren Jiangping;Guo Jianxin(Radiotherapy and Chemotherapy Center,Ningbo First Hospital,Ningbo 315000,China;Radiotherapy Technology Department,Yuyao People's Hospital,Ningbo 315400,China;Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Scicences and Peking Union Medical College,Beijing 100021,China;Radiotherapy Department,Huaxian People's Hospital of Henan,Anyang 456400,China;Radiotherapy Department,Xingyi People's Hospital,Xingyi 562400,China)

机构地区：[1]宁波市第一医院放化疗中心,宁波315000 [2]浙江省余姚市人民医院放疗技术科,宁波315400 [3]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021 [4]河南省滑县人民医院放疗科,安阳456400 [5]贵州省兴义市人民医院放疗科,兴义562400

出　　处：《中华放射医学与防护杂志》2022年第4期262-268,共7页Chinese Journal of Radiological Medicine and Protection

基　　金：余姚市医疗卫生科技计划平台项目(2021YPT02)。

摘　　要：目的比较左侧乳腺癌患者根治术后常规调强放射治疗计划(intensity modulated radiotherapy,IMRT)与电子束适形放疗(electron beam conformal radiotherapy,EBCRT)联合调强放疗计划的剂量学差异。方法选择2018年6月至2021年10月于宁波市第一医院放化疗中心收治的20例左侧乳腺癌根治术后患者资料,计划靶区(plan target volume,PTV)包括锁骨上下淋巴结引流区域计划靶区(PTV_(sc))和患侧胸壁计划靶区(PTV_(cw)),处方剂量均为50 Gy/25次。所有患者均采用美国Varian Eclipse治疗计划系统(treatment planning system,TPS)设计两种放疗计划,然后对比两种放疗计划的剂量学参数差异。结果所有20例患者的IMRT计划全部满足临床要求,与此同时EBCRT联合IMRT计划中有2例患者因患侧肺剂量参数超出本单位的剂量限定标准而不被临床接受,两例失败计划的胸壁最大深度分别为3.7和4.4 cm,使用的电子束能量分别为12和15 MeV。其余18例患者的胸壁深度均≤3 cm,使用9 MeV及以下能量电子束进行EBCRT联合IMRT计划设计,靶区和各危及器官剂量均满足临床要求,并与IMRT计划进行剂量学配对比较。常规IMRT的均匀性指数(HI)均优于EBCRT联合IMRT计划(t_(PTV_(sc))=-10.20、t_(PTV_(cw))=-9.24,P<0.05);常规IMRT整体靶区适形指数(CI)与EBCRT联合IMRT计划比较差异有统计学意义(t_(PTVall)=10.39,P<0.05)。对于危及器官(organ at risk,OARs),EBCRT联合IMRT计划患侧肺的V_(5 Gy)、V_(20 Gy)和D_(mean)均较IMRT更低,差异有统计学意义(t=5.98、6.30、11.30,P<0.05);心脏的V_(25 Gy)和D_(mean)分别降低了8.3%和4.79 Gy(t=15.23、15.76,P<0.05);冠状动脉左前降支(left anterior descending coronary artery,LADCA)的D_(mean)降低了44.03%(t=11.69,P<0.05);健侧乳腺的V_(5 Gy)和D_(mean)分别降低了7.9%和0.8 Gy(t=3.66、4.932 P<0.05);其他OARs剂量差异均无统计学意义(P>0.05)。结论对于胸壁靶区深度≤3 cm的左侧乳腺癌根治术后患者,EBCRT联合IMRT能显�Objective To investigate the dosimetric differences between conventional IMRT and electron beam conformal radiotherapy(EBCRT)combined with IMRT for post-mastectomy left-sided breast cancer patients.Methods A total of 20 post-mastectomy left-sided breast cancer patients who were treated in the Ningbo First Hospital from June 2018 to October 2021 were retrospectively studied.The planning target volume(PTV)included the supra-and infra-clavicular regions(PTV_(sc))and the ipsilateral chest wall(PTV_(cw)),and the prescribed dose was 50 Gy/25 f.All radiotherapy plans were designed using the Varian Eclipse treatment planning system(TPS).After that,the dose distribution of the target volume and the dose exposure of organs at risk(OARs)were compared and analyzed.Results All the IMRT plans met the clinical requirements,yet 2/20 of the EBCRT combined with IMRT plans were not clinically accepted.For these two patients,the maximum chest wall thickness was 3.7 cm and 4.4 cm each,and the designed electron beam energy was 12 MeV and 15 MeV,respectively.The dose to the ipsilateral lung of these two patients exceeded the institution-specific dose limit standard.For the remaining 18 patients whose chest wall thickness was 3 cm or less,the designed electron beams were 9 MeV or less.All the EBCRT combined with IMRT plans were clinically accepted.The target dose distribution of the conventional IMRT was better than that of the EBCRT combined with IMRT(uniformity index(HI):PTV_(sc):t=-10.20,P<0.05;PTV_(cw):t=-9.24,P<0.05;conformal index(CI):PTV_(all):t=10.39,P<0.05).For OARs,the V_(5 Gy),V_(20 Gy),and D_(mean) of the ipsilateral lung of EBCRT combined with IMRT were lower than those of IMRT(t=5.98,6.30,11.30,P<0.05).Specifically,the V_(25 Gy) and D_(mean) of heart decreased by 8.3% and 4.79 Gy,respectively(t=15.23,15.76,P<0.05),the D_(mean) of the left anterior descending coronary artery(LADCA)decreased by 44.03%(t=11.69,P<0.05),and the V_(5 Gy) and D_(mean) of the contralateral breast decreased by 7.9% and 0.8 Gy,respectively(t=3.66,4.

关 键 词：乳腺癌 根治术 电子束适形放疗 调强放疗 剂量学 

分 类 号：R737.9[医药卫生—肿瘤]