地黄除风益损汤联合氟米龙滴眼液改善胬肉术后眼表状态的疗效观察  

Clinical Observation of Dihuangchufengyisuntang Combined with Flumilone Eye Drops on Improving Ocular Surface State after Pterygium Operation

作　　者：陈黛茜 袁拯忠[1] 陈成春[2] 刘艳莉[3] Daixi Chen;Zhengzhong Yuan;Chengchun Chen;Yanli Liu(Department of Traditional Chinese Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China;Department of Human Anatomy of Wenzhou Medical University,Wenzhou 325000,China;Department of Ophthalmology,Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310006,China)

机构地区：[1]温州医科大学附属第一医院中医科,温州325000 [2]温州医科大学解剖学教研室,温州325000 [3]浙江省中医院眼科,杭州310006

出　　处：《中华眼视光学与视觉科学杂志》2022年第2期97-100,共4页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：浙江省自然科学基金(LGF19C110001);浙江省中医药优秀青年人才基金(2019ZQ019)。

摘　　要：目的:观察地黄除风益损汤(自拟方)联合氟米龙滴眼液改善翼状胬肉术后眼表状态的临床疗效。方法:系列病例研究。选取在浙江省中医院眼科行翼状胬肉的患者60例,随机分为治疗组30例(38眼)和对照组28例(38眼)。治疗组术后使用地黄除风益损汤联合0.1%氟米龙滴眼液治疗,对照组术后仅予0.1%氟米龙滴眼液治疗,共治疗6周。并分别于治疗2、4、6周行角膜荧光素钠染色(FL)、泪膜破裂时间(BUT)和泪液分泌试验(SⅠT),并参照《中药新药临床研究指导原则》拟定中医临床症状目痛、目痒、眼眵、流泪、眼干涩、白睛红赤、羞明畏光积分,记录各项检测指标数值及症状积分。采用重复方差分析、t检验、秩和检验和卡方检验进行统计学分析。结果:治疗2周时,2组间症状积分对比差异有统计学意义(t=2.97,P=0.01),而FL、BUT、SⅠT对比差异无统计学意义。治疗4、6周时,2组间症状积分、FL、BUT、SⅠT对比差异均有统计学意义(4周:t=-4.03、-4.42、5.01、4.16;6周:t=-2.18、-2.02、2.08、2.31;均P<0.05)。结论:地黄除风益损汤联合氟米龙滴眼液治疗能明显改善翼状胬肉术后眼表刺激症状,减少角膜荧光素钠染色,延长BUT,增加泪液分泌量,临床疗效显著。Objective:To observe the clinical treatment of Dihuangchufengyisuntang(self-made prescription)combined with flumilone eye dropson improving the ocular surface state after pterygium surgery.Methods:In this serial case study,select 60 patients who have made pterygium surgery,and randomly divided them into treatment group 30 cases(38 eyes)and control group 28 cases(38 eyes).The treatment group was treated with Dihuangchufengyisuntang combined with 0.1%flumilone eye drops,while the control group was treated with 0.1%flumilone eye drops only,and the treatment lasted for 6 weeks.Corneal sodium fluorescein staining(FL),SchirmerⅠtest(SⅠT)and break-up time(BUT)were performed at 2,4 and 6 weeks of treatment,respectively.Eye pain,eye itching,eye discharge,lacrimation,dryeye,conjunctival congestion,photophobia scores of Traditional Chinese Medicine treatment(TCM)clinical sympotoms were determined according to Guidelines for Clinical Research of TCM New Drugs.All test indicators and symptom scores were recorded.Data were analyzed by repetitive measurement deviation analysis,t text,rank sum test and chi-square test.Results:After 2 weeks of treatment,there was statistically significant difference in symptoms scores between the two groups(t=2.97,P=0.01).While there was no significant difference in FL,SⅠT,BUT.At 4,6 weeks of treatment,symptoms scores,FL,SⅠt,BUT were significantly different between the two groups(after 4 weeks of treatment,t values are-4.03,-4.42,5.10,4.16;after 6 weeks of treatment,t values are-2.18,-2.02,2.08,2.31;P<0.05).Conclusion:Dihuangchufengyisuntang combined with flumilone eye drops can obviously improve the ocular surface irritation symptoms after pterygium operation,reduce corneal fluorescein sodium staining,prolong the tear film rupture time,increase the tear secretion,and the clinical effect is significant and stable.

关 键 词：翼状胬肉术后 中药治疗 眼表 

分 类 号：R779.6[医药卫生—眼科]