NGF、TrkA及c-Met表达对原发性上皮性卵巢癌病情评估及预后预测的作用  

Study on value of expression of NGF,TrkA and c-Met of patients with primary epithelial ovarian cancer in disease evaluation and prognosis prediction

作　　者：刘海龙[1,2] 李娟 董小鑫 黄翠兰 LIU Hailong;LI Juan;DONG Xiaoxin;HUANG Cuilan(Xi'an Jiaotong University,Xi'an 710000,China;Yuechi People's Hospital,Guang'an,638300,Sichuan,China;The Ninth Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710000,China)

机构地区：[1]西安交通大学,陕西西安710000 [2]岳池县人民医院,四川广安638300 [3]西安交通大学医学院附属西安市第九医院,陕西西安710000

出　　处：《西部医学》2022年第5期665-670,674,共7页Medical Journal of West China

基　　金：陕西省重点研发计划(2016SF-039)。

摘　　要：目的分析NGF、TrkA及c-Met表达对原发性上皮性卵巢癌病情评估、预后预测的作用。方法收集岳池县人民医院2016年6月~2018年6月收治的115例原发性上皮性卵巢癌患者为研究对象,所有患者均行手术治疗,将卵巢癌患者作为癌组织组,将对侧正常卵巢组织作为正常组织组。采用免疫组化方法检测各组组织中NGF、TrkA及c-Met指标,比较各组组织中NGF、TrkA及c-Met表达情况;分析NGF、TrkA及c-Met与原发性上皮性卵巢癌患者各病理参数的相关性;统计原发性上皮性卵巢癌患者预后情况,以Kaplan-Meier生存分析NGF、TrkA及c-Met表达对原发性上皮性卵巢癌患者预后生存的影响;采用多元Logistic回归分析对原发性上皮性卵巢癌患者预后生存的危险因素进行分析;采用ROC曲线分析NGF、TrkA及c-Met表达在原发性上皮性卵巢癌患者预后生存中的预测价值。结果癌组织组NGF、TrkA及c-Met阳性表达率显著高于正常组织组,差异具有统计学意义(P<0.05);原发性上皮卵巢癌患者中NGF、TrkA及c-Met表达与年龄、组织分化类型、腹腔积液无明显相关性(P>0.05);而与淋巴结转移、临床分期、分化程度有相关性(P<0.05);115例患者经两年随访后显示,两年生存率为35.65%(41/115)。生存分析显示NGF、TrkA及c-Met表达阴性者生存期较阳性表达者长(P<0.05)。分化程度、临床分期、淋巴转移、NGF、TrkA及c-Met阳性为影响原发性上皮卵巢癌患者预后生存的独立危险因素(P<0.05);ROC曲线显示,NGF、TrkA及c-Met及三者联合曲线下面积分别为0.780、0.851、0.808、0.946,各指标曲线下面积以联合检测最大。结论NGF、TrkA及c-Met与原发性上皮卵巢癌患者病情评估及预后密切相关,临床监测该水平对患者病情评估及预后具有重要作用。Objective To analyze the value of expression of NGF,TrkA and c-Met of patients with primary epithelial ovarian cancer in disease evaluation and prognosis prediction.Methods 115 patients with primary epithelial ovarian cancer treated in Yuechi People′s Hospital from June 2016 to June 2018 were selected as the research objects.All patients were treated with surgery.The tumor tissue and the normal tissue adjacent to the tumor were collected as the cancer tissue group(n=115)and adjacent normal tissue group(n=115).Immunohistochemical method was used to detect NGF,TrkA and c-Met indicators.The expressions of NGF,TrkA,and c-Met in tissues were compared.The correlation between expression of NGF,TrkA and c-Met and the pathological parameters of patients with primary epithelial ovarian cancer was analyzed.The prognosis of patients with primary epithelial ovarian cancer was counted.Kaplan-Meier survival analysis was used to analyze the effect of NGF,TrkA and c-Met expression on the prognostic survival of patients with primary epithelial ovarian cancer.Multivariate Logistic regression was used to analyze the risk factors affecting the prognosis survival of patients with primary epithelial ovarian cancer.ROC was used to analyze the predictive value of NGF,TrkA and c-Met expression for the prognostic survival of patients with primary epithelial ovarian cancer.Results The positive expression rates of NGF,TrkA and c-Met in the cancer tissue group were significantly higher than those in the adjacent normal tissue group,and the difference was statistically significant(P<0.05).The expression of NGF,TrkA and c-Met in patients with primary epithelial ovarian cancer were not significantly correlated with age,type of tissue differentiation,and seroperitoneum(P>0.05).Lymph node metastasis and clinical stage were correlated with the expression of NGF,TrkA and c-Met(P<0.05).③115 patients were followed up for 2 years.The results showed that the 2-year survival rate was 57.39%(66/115).Survival analysis showed that the patients with nega

关 键 词：NGF TRKA C-MET 原发性上皮卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]