超声及BRAF^(V600E)基因对甲状腺乳头状癌颈部淋巴结转移的预测因素  

Predictor research of ultrasound characteristics and BRAF^(V600E) gene mutation with cervical lymph node metastasis in papillary thyroid carcinoma

作　　者：刘晓琳 陈欣欣[1] 陈铃[1] 林鸿国[2] LIU Xiao-lin;CHEN Xin-xin;CHEN Ling;LIN Hong-guo(Department of Ultrasound Imaging,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,Guangdong,China;不详)

机构地区：[1]广东省中医院超声影像科,广东广州510120 [2]广东省中医院甲状腺诊治中心,广东广州510120

出　　处：《广东医学》2022年第4期457-461,共5页Guangdong Medical Journal

基　　金：广东省科技计划项目(2017ZC0162)。

摘　　要：目的探讨甲状腺乳头状癌(PTC)超声征象及BRAF^(V600E)基因与颈部淋巴结转移的相关性。方法回顾性分析病理诊断为甲状腺乳头状癌136例患者,178个甲状腺癌结节,83枚颈部淋巴结的超声影像学资料和BRAF^(V600E)基因结果,分析BRAF^(V600E)基因、各超声特征与颈部淋巴结转移的相关因素。结果单因素分析结果显示:多发病灶、年龄<40岁、结节最大径≥1.5 cm、微钙化、甲状腺包膜侵犯、BRAF^(V600E)基因突变与甲状腺乳头状癌颈部淋巴结转移的发生有关(P<0.05);多变量分析结果显示:甲状腺包膜侵犯、BRAF^(V600E)基因突变是颈部淋巴结转移的危险因素(OR=2.701、3.282,均P<0.05)。结论甲状腺包膜侵犯、BRAF^(V600E)基因突变的甲状腺乳头状癌患者,更易发生颈部淋巴结转移。Objective To investigate the correlations of ultrasound characteristics and BRAF^(V600E)gene with cervical lymph node metastasis(CLNM)in papillary thyroid carcinoma(PTC).Methods The ultrasound data of 136 cases of PTC,including 178 thyroid nodules,83 cervical lymph nodes and BRAF^(V600E)gene from November 2018 to July 2019 in our hospital were retrospectively collected.To investigate the correlation of ultrasound characteristics and BRAF^(V600E)gene with CLNM in PTC.Results Single factor analysis results showed that multifocality,age<40 years,nodule diameter≥1.5 cm,microcalcification,invasion outside the thyroid capsule and BRAF^(V600E)gene mutation were significantly correlated to CLNM(P<0.05).Multivariate analysis showed that invasion outside the thyroid capsule and BRAF^(V600E)gene mutation were independent risk factor for CLNM(OR=2.701 and 3.282,respectively,P<0.05).Conclusion The PTC patients with invasion outside the thyroid capsule and BRAF^(V600E)gene mutation are more likely to develop CLNM.

关 键 词：超声特征 BRAF^(V600E)基因 甲状腺乳头状癌 颈部淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤] R445.1[医药卫生—临床医学]