Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications  

作　　者：Hernando Lopez-Bertoni Amanda Johnson Yuan Rui Bachchu Lai Sophie Sail Maureen Malloy Jonathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo Jordan J.Green John Laterra 

机构地区：[1]Hugo W.Moser Research Institute at Kennedy Krieger,Baltimore,MD,USA [2]Department of Neurology,Johns Hopkins University School of Medicine,Baltimore,MD,USA [3]Department of Biomedical Engineering,Institute for NanoBioTechnology,and the Translational Tissue Engineering Center,Johns Hopkins University School of Medicine,Baltimore,MD,USA [4]Bloomberg School of Public Health,Department of Environmental Health and Engineering,The Johns Hopkins University School of Medicine,Baltimore,MD,USA [5]The Department of Radiation Oncology and Molecular Radiation Sciences,The Johns Hopkins University School of Medicine,Baltimore,MD,USA [6]Department of Ophthalmology,Johns Hopkins University School of Medicine,Baltimore,MD,USA [7]Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,MD,USA [8]Departments of Materials Science&Engineering and Chemical&Biomolecular Engineering,Johns Hopkins University,Baltimore,MD,USA [9]Department of Neurosurgery,Johns Hopkins University School of Medicine,Baltimore,MD,USA [10]Department of Neuroscience,Johns Hopkins University School of Medicine,Baltimore,MD,USA

出　　处：《Signal Transduction and Targeted Therapy》2022年第3期790-801,共12页信号转导与靶向治疗（英文）

摘　　要：DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5mC are widely reported in human cancers and loss of 5hmC correlates with poor prognosis.

关 键 词：TET2 5hmC CONVERT 

分 类 号：R73[医药卫生—肿瘤]