Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus  

作　　者：Xiaojuan Han Tianshu Xu Congzhu Ding Dandan Wang Genhong Yao Hongwei Chen Qijun Fang Gang Hu Lingyun Sun 

机构地区：[1]Department of Rheumatology and Immunology,Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,China [2]Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,China [3]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,China [4]Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第3期840-855,共16页信号转导与靶向治疗（英文）

基　　金：This research was supported by grants from the National Key R&D Program of China(2020YFA0710800);the Key Program of National Natural Science Foundation of China(81930043);the Major International(Regional)Joint Research Project of China(81720108020);the National Natural Science Foundation of China(81903587);the Jiangsu Provincial Key Research and Development Program(BE2020621);the China Postdoctoral Science Foundation(2019M661807&2021T140315);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(2020YLXK006).

摘　　要：Neuropsychiatric lupus(NPSLE)is a frequent manifestation of systemic lupus erythematosus(SLE)that occurs in 40-90%of SLE patients;however,the underlying mechanisms remain elusive,causing a severe lack of therapeutic targets for this condition.Here,we show that complement-coordinated elimination of synapses participated in NPSLE in MRL/lpr mice,a lupus-prone murine model.We demonstrated that lupus mice developed increased anxiety-like behaviors and persistent phagocytic microglial reactivation before overt peripheral lupus pathology.

关 键 词：LUPUS COORDINATED pathology 

分 类 号：R74[医药卫生—神经病学与精神病学]