液体活检在消化道肿瘤诊治中的应用进展  

Application progress of liquid biopsy in the diagnosis and treatment of gastrointestinal tumors

作　　者：Jun Yu Jun Yu(Departments of Surgery,the Johns Hopkins University School of Medicine,Baltimore 21218,United States)

机构地区：[1]美国约翰霍普金斯医院外科,巴尔的摩21218

出　　处：《中华结直肠疾病电子杂志》2022年第2期104-107,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

摘　　要：液态活检作为一种新兴的无创检测技术,主要包括循环肿瘤细胞、循环肿瘤DNA、微小RNA以及外泌体等生物标志物的检测,在肿瘤早期诊断、监测疾病进展以及疗效评价等方面的应用日趋普遍。近年来,以胰腺癌、结直肠癌和胃癌等为代表的消化系统肿瘤成为威胁我国人民群众身体健康的重要疾病负担,并且多数患者确诊时已为中晚期。因此,如何完善消化系统肿瘤的诊断和筛查手段,延长患者的生存期,是当前的研究重点。本文就液态活检在消化系统肿瘤诊治中的临床应用现状和前景进行探讨。As an emerging non-invasive detection technology,liquid biopsy mainly includes the detection of biomarkers such as circulating tumor cells,circulating tumor DNA,microRNA,and exosomes.In recent years,tumors of the digestive system,represented by pancreatic cancer,colorectal cancer,and gastric cancer,have become a vital disease burden that threatens the health of the Chinese people,and most patients are diagnosed in the advanced stages.Therefore,how to improve the diagnosis and screening methods of digestive system tumors and prolong the survival period of patients should become the current research focus.This review discusses the status and prospects of the clinical application of liquid biopsy in the diagnosis and treatment of digestive system tumors.

关 键 词：循环肿瘤细胞 肿瘤早期诊断 消化系统肿瘤 疾病负担 外泌体 循环肿瘤DNA 肿瘤诊治 疾病进展 

分 类 号：R73[医药卫生—肿瘤]