高危型人乳头瘤病毒联合薄层液基细胞学对宫颈癌及癌前病变患者诊断效能的影响  

Influence of High-risk Human Papillomavirus Combined with Thin-layer Liquid-based Cytology on the Diagnostic Performance of Cervical Cancer and Precancerous Lesions

作　　者：赵卫[1] 刘萌萌[1] ZHAO Wei;LIU Meng-meng(Outpatient Department,Luoyang Center for Disease Control and Prevention,Luoyang,Henan,471023,China)

机构地区：[1]洛阳市疾病预防控制中心门诊部,河南洛阳471023

出　　处：《黑龙江医学》2022年第8期915-917,共3页Heilongjiang Medical Journal

摘　　要：目的:研究高危型人乳头瘤病毒(HR-HPV)联合薄层液基细胞学(TCT)对宫颈癌及癌前病变患者诊断效能的影响。方法:选取洛阳市疾病预防控制中心166例疑似宫颈癌及癌前病变患者,均行HR-HPV、TCT检查,以病理结果为金标准,比较HR-HPV联合TCT及两者单项检查的诊断效能。结果:病理结果证实,166例疑似宫颈癌及癌前病变患者中,炎症74例,宫颈癌及癌前病变患者92例,包括CINⅠ级16例,CINⅡ级20例,CINⅢ级24例,宫颈癌32例。HRHPV联合TCT诊断准确率87.95%高于两者单项检查的79.52%、75.90%,敏感度97.83%高于两者单项检查诊断敏感度82.61%、75.00%,差异有统计学意义(χ^(2)=8.288、19.651,P<0.05)。HR-HPV联合TCT诊断特异度75.68%与两者单项检查75.68%、77.03%相比,差异无统计学意义(χ^(2)=0.05,P>0.05)。宫颈癌患者HR-HPV、TCT阳性率100.00%、96.97%高于CINⅢ级(74.07%、66.67%)、CINⅡ级(72.22%、61.11%)、CINⅠ级患者(71.43%、57.14%)。不同CIN分级患者HRHPV、TCT阳性率,差异无统计学意义(χ^(2)=10.886、13.728,P>0.05)。结论:HR-HPV联合TCT应用于宫颈癌及癌前病变患者中诊断价值较高,且能有效鉴别宫颈癌与癌前病变,有助于为临床提供参考依据,值得临床推广。Objective:To study the effect of high-risk human papillomavirus(HR-HPV)combined with thin-layer liquidbased cytology(TCT)on the diagnostic performance of cervical cancer and precancerous lesions.Methods:A total of 166 patients with suspected cervical cancer and precancerous lesions in the center were selected,and all underwent HR-HPV and TCT examinations.Pathological results were used as the gold standard.The diagnostic efficacy of HR-HPV combined with TCT and the two single examinations was compared.Results:Pathological results confirmed that among the 166 patients with suspected cervical cancer and precancerous lesions,74 were inflamed,and 92 were cervical cancer and precancerous lesions,including 16 CINⅠ,20CINⅡ,24 CINⅢ,and 32 cervical cancer.The diagnostic accuracy rate of HR-HPV combined with TCT was 87.95%,which was higher than 79.52% and 75.90% of the two alone.The sensitivity was 97.83%,which was higher than the 82.61% and 75.00% of the two separate inspections,and the difference was statistically significant(χ^(2)=8.288,19.651,P<0.05).tThe diagnostic specificity of HR-HPV combined with TCT was 75.68%,compared with 75.68%and 77.03%of the two alone,there was no significant difference(χ^(2)=0.05,P>0.05).The positive rates of HR-HPV and TCT in cervical cancer patients were 100.00% and 96.97%,which were higher than those of CINⅢ(74.07%,66.67%),CINⅡ(72.22%,61.11%)and CINⅠ(71.43%,57.14%).There was no statistically significant difference in the positive rates of HR-HPV and TCT in patients with different CIN grades(χ^(2)=10.886,13.728,P>0.05).Conclusion:HR-HPV combined with TCT has high diagnostic value in patients with cervical cancer and precancerous lesions,and can effectively identify cervical cancer and precancerous lesions,which is helpful to provide clinical reference and is worthy of clinical promotion.

关 键 词：宫颈癌 高危型人乳头瘤病毒 薄层液基细胞学 诊断效能 

分 类 号：R737.33[医药卫生—肿瘤]