缺氧诱导因子氧感知信号通路与“高氧-低氧悖论”的研究进展  

Oxygen-sensing pathway of hypoxia-inducible factor and“hyperoxic-hypoxic paradox”:research progress

作　　者：孟祥阳 王蒙蒙[2] 张坤[1] 徐伟刚[1] MENG Xiang-yang;WANG Meng-meng;ZHANG Kun;XU Wei-gang(Department of Diving and Hyperbaric Medical Research,Naval Medical Center,Naval Medical University(Second MilitaryMedical University),Shanghai 200433,China;Department of Hyperbaric Oxygen and Neurology,Naval Medical Center,Naval Medical University(Second Military MedicalUniversity),Shanghai 200052,China)

机构地区：[1]海军军医大学(第二军医大学)海军特色医学中心潜水与高气压医学研究室,上海200433 [2]海军军医大学(第二军医大学)海军特色医学中心高压氧神经内科,上海200052

出　　处：《海军军医大学学报》2022年第4期433-437,共5页Academic Journal of Naval Medical University

基　　金：海军军医大学(第二军医大学)“启航”专项(20X2701);海军军医大学(第二军医大学)海军特色医学中心第二轮“打仗型”基金科研专项(20M2702);海军军医大学(第二军医大学)海军特色医学中心优秀青年教师引进人才项目(2020SZ-22)。

摘　　要：氧稳态对细胞功能的维持至关重要,缺氧诱导因子(HIF)氧感知信号通路在氧浓度调节及氧稳态维持中发挥了十分重要的作用。高氧至常氧、常氧至低氧的变换会使细胞处于相对缺氧状态,可触发通常由缺氧引发的细胞内级联反应,增强细胞对抗缺氧的能力,这种现象被称为“高氧-低氧悖论”(HHP),其机制与HHP诱导HIF-1α表达上调有关。本文就HIF氧感知信号通路与HHP的研究进展进行综述。Oxygen homeostasis is crucial for the maintenance of cell function.Hypoxia-inducible factor(HIF)oxygen-sensing pathway plays an important role in the regulation of oxygen concentration and the maintenance of oxygen homeostasis.The change from hyperoxia to normoxia or from normoxia to hypoxia can put cells in a relatively hypoxic state,and it can trigger the intracellular cascade reaction usually triggered by hypoxia and enhance the ability of cells to resist hypoxia.This phenomenon is called“hyperoxic-hypoxic paradox”(HHP),and its mechanism is related to the up-regulation of HIF-1αinduced by HHP.This paper reviews the research progress of HIF oxygen-sensing pathway and HHP.

关 键 词：氧稳态 缺氧诱导因子 高氧-低氧悖论 氧感知通路 

分 类 号：R364.4[医药卫生—病理学]