Artificial oxygen carriers,from nanometer-to micrometer-sized particles,made of hemoglobin composites substituting for red blood cells  

作　　者：Takashi Matsuhira Hiromi Sakai 

机构地区：[1]Department of Chemistry,Nara Medical University,840 Shijo-cho,Kashihara 634-8521,Japan

出　　处：《Particuology》2022年第5期43-55,共13页颗粒学报（英文版）

基　　金：supporting to our research group with grants from the Japan Society for the Promotion of Science (JSPS);the Japan Agency for Medical Research and Development(AMED).

摘　　要：Blood transfusions are regarded as the most well-known and frequently performed cell transplantations.Although current transfusion systems are sophisticated,they cannot be freed from the inherent difficulties that include infection,short shelf life,and blood type mismatching.Artificial oxygen carriers produced using hemoglobin(Hb)are designated as Hb-based oxygen carriers(HBOCs),which are anticipated for use as biomaterials that have potential to resolve issues of transfusion by a radical paradigm shift.Various HBOCs,nanometer-sized to micrometer-sized bioparticles having an oxygen-carrying function,are developed for use as substitutes for red blood cells(RBCs).This paper presents an overview of the classification of HBOCs with reference to their histories,preparations,structures,functions,and in vitro and in vivo properties.Additionally,we give a more detailed introduction of our academic studies of liposome encapsulated Hb,designated as Hb-vesicles(HbV),which mimic the physiologically important corpuscular structure of RBCs.This review outlines perennial efforts and approaches to mimic RBC functions through chemical,genetic,and encapsulation techniques.It will provide important insights into the eventual realization of an alternative for RBC transfusion.

关 键 词：Blood substitutes Cross-linking Hemoglobin(Hb)-based oxygen carriers(HBOCs) LIPOSOME Supramolecular assembly Transfusion alternatives 

分 类 号：R318[医药卫生—生物医学工程]