Early brainstem hemorrhage progression:multi-sequence magnetic resonance imaging and histopathology  

作　　者：Xi Guo Jia-Ke Xu Xin Qi Yang Wei Cheng-Wei Wang Hao Li Lu Ma Chao You Meng Tian 

机构地区：[1]Department of Neurosurgery and Neurosurgery Research Laboratory,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China [2]Department of Integrated Traditional and Western Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China [3]Department of Rehabilitation,People’s Hospital of Karamay,Karamay,Xinjiang Uygur Autonomous Region,China [4]West China Brain Research Center,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China

出　　处：《Neural Regeneration Research》2023年第1期170-175,共6页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2020D01A13 (to CWW);Chengdu Science and Technology Bureau, No. 2019-YF05-00511-SN (to MT);1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, Nos. ZY2016102 (to MT), and ZY2016203 (to CY)

摘　　要：According to clinical statistics,the mortality of patients with early brainstem hemorrhage is high.In this study,we established rat models of brainstem hemorrhage by injecting type Ⅶ collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods.We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days.The edema that occurred was mainly of the vasogenic type.No complete myelin sheath structure was found around the focus of the brainstem hemorrhage.The integrity and continuity of nerve fibers gradually deteriorated over the first 7 days.Neuronal degeneration was mild in the first 3 days and then obviously aggravated on the 7^(th)day.Inflammatory cytokines,interleukin-1β,and tumor necrosis factorαappeared on the 1st day after intracerebral hemorrhage,reached peak levels on the 3^(rd)day,and decreased from the 7^(th)day.Our findings show the characteristics of the progression of early brainstem hemorrhage.

关 键 词：brainstem hemorrhage diffuse tensor imaging diffusion-weighted imaging Fluoro-Jade C staining hematoxylin-eosin staining INTERLEUKIN-1Β luxol fast blue rat model T2-weighted imaging tumor necrosis factor-α 

分 类 号：R445.2[医药卫生—影像医学与核医学]