益气养阴、化瘀祛风方对原发性干燥综合征患者外分泌腺功能、炎症因子及免疫功能影响  

Effects of YiqiYangyin HuayuQufeng Formula on Exocrine Gland Function, Inflammatory Factors, and Immune Function in Patients with Primary Sjogren′s Syndrome

作　　者：郭伟民 项德坤 贾军峰[2] 李雪梅[2] GUO Wei-min;XIANG De-kun;JIA Jun-feng;LI Xue-mei(Department of Rheumatology and Immunology,980 Hospital,Joint Logistics Support Force,Handan Hebei056000;Department of Rheumatology and Immunology,Handan Hospital of Traditional Chinese Medicine,Handan Hebei056001)

机构地区：[1]联勤保障部队第九八〇医院风湿免疫科,河北邯郸056000 [2]邯郸市中医院风湿免疫科,河北邯郸056001

出　　处：《世界中西医结合杂志》2022年第3期546-550,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2020579)。

摘　　要：目的 观察益气养阴、化瘀祛风方对原发性干燥综合征患者外分泌腺功能、炎症因子及免疫功能的影响。方法 选取2016年2月—2020年12月期间于联勤保障部队第九八〇医院就诊的原发性干燥综合征患者64例,按照随机数字表法分为对照组和治疗组,每组各32例。对照组给予西医常规治疗,治疗组在对照组基础上给予益气养阴、化瘀祛风方治疗,疗程均为3个月。治疗3个月后,观察两组治疗前后中医证候评分,外分泌腺功能即唾液流量、自然唾液流率、泪液分泌试验,血清炎性因子水平即白介素-17(Interleukin-17,IL-17)、干扰素-γ(Interferon-γ,IFN-γ),免疫功能即CD8^(+)T细胞、CD19^(+)CD5^(+)B淋巴细胞及干燥综合征疾病自我感受(ESSPRI)评分、干燥综合征疾病活动度(ESSDAI)评分。结果 治疗后两组患者口腔干燥积分、眼部干燥积分、眼部红赤积分、腮腺肿痛积分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组下降水平较对照组更明显,差异有统计学意义(P<0.05)。治疗后治疗组唾液流量、泪液分泌量、自然唾液流率均较治疗前升高,差异有统计学意义(P<0.05);对照组均较治疗前升高,差异有统计学意义(P<0.05);且治疗组唾液流量、自然唾液流率升高水平较对照组更明显,差异有统计学意义(P<0.05)。治疗后两组患者IL-17、IFN-γ水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组下降水平较对照组更明显,差异有统计学意义(P<0.05)。两组患者治疗后CD8^(+)T细胞水平比较治疗前上升,CD19^(+)CD5^(+)B淋巴细胞水平较治疗前下降,差异有统计学意义(P<0.05);且治疗组优于照组,差异有统计学意义(P<0.05)。治疗后两组患者ESSPRI、ESSDAI评分均治疗前降低,差异有统计学意义(P<0.05);且治疗组下降水平高于对照组,差异有统计学意义(P<0.05)。结论 益气养阴、祛风化瘀方可明显降低血清炎症因子水平,促进CD8^(Objective To observe the effects of YiqiYangyin HuayuQufeng Formula(YYHQ)on exocrine gland function, inflammatory factors, and immune function in patients with primary Sjogren′s syndrome.Methods Sixty-four patients with primary Sjogren′s syndrome admitted to the 980 Hospital of the Joint Logistics Support Force from February 2016 to December 2020 were enrolled and randomly divided into a treatment group(32)and a control group(32)according to a random number table.The patients in the control group were treated with conventional western medicine, and those in the treatment group were treated with YYHQ on the basis of the therapeutic protocol of the control group.All patients were treated for three months.The scores of traditional Chinese medicine(TCM)syndromes, exocrine gland functions(salivary flow, natural saliva flow rate, and Schirmer′s test),serum levels of inflammatory factors[interleukin-17(IL-17)and interferon-γ(IFN-γ)],content of CD8^(+)T cells and CD19^(+)CD5^(+)B lymphocytes, EULAR Sjogren′s Syndrome Patient Reported Index(ESSPRI)scores, and EULAR Sjogren′s Syndrome Disease Activity Index(ESSDAI)scores of the two groups before and after treatment were observed and compared.Results After treatment, the scores of dry mouth, dry eyes, redeyes, and parotid gland swelling pain in the two groups decreased(P<0.05),and the decrease in the treatment was more significant than that in the control group(P<0.05).After treatment, the salivary flow, tear secretion, and natural saliva flow rate in the treatment group increased compared with those before treatment(P<0.05),and the salivary flow and natural saliva flow rate in the control group were higher than those before treatment(P<0.05).Additionally, the increase in the treatment group was more significant than that in the control group(P<0.05).After treatment, the levels of IL-17 and IFN-γ in the two groups were lower than those before treatment(P<0.05),and the decrease in the treatment was more significant than that in the control group(P<0.05).After tr

关 键 词：益气养阴、化瘀祛风方 干燥综合征 外分泌腺功能 炎症因子 免疫功能 

分 类 号：R777.34[医药卫生—眼科]