康艾注射液治疗对子宫颈癌术后患者免疫功能、IGF-2、STMN1、SCC变化的影响  

Effects of Kangai injection on immune function,IGF-2,STMN1 and SCC of postoperative patients with cervical cancer

作　　者：连立芬 高亚梅 赵鑫 李鹏利 LIAN Li-fen;GAO Ya-mei;ZHAO Xin(Department of Gynecology,Qinhuangdao Maternal and Child Health Care Hospital,Qinhuangdao Hebei 066000,China.)

机构地区：[1]秦皇岛市妇幼保健院妇科,河北秦皇岛066000

出　　处：《临床和实验医学杂志》2022年第8期894-896,F0003,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省科技计划项目(编号:14397702D)。

摘　　要：目的 研究康艾注射液治疗对子宫颈癌术后患者免疫功能、胰岛素样生长因子-2(IGF-2)、重组人微管解聚蛋白-1(STMN1)、鳞状细胞癌相关抗生素(SCC)变化的影响。方法 采用回顾性分析方法,选取2020年月1月至2021年6月秦皇岛市妇幼保健院收治入院的62例子宫颈癌患者作为研究对象,按照治疗方式不同分为研究组(n=31)与对照组(n=31)。两组患者术前均行新辅助化疗,然后接受开腹根治性宫颈切除手术治疗,对照组术后行常规对症治疗,研究组基于常规疗法行康艾注射液治疗。比较两组治疗前后免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、IGF-2、STMN1、SCC、细胞角蛋白19片断抗原(CYFRA21-1)、血清Th1/Th2细胞相关因子[干扰素-γ(INF-γ)、白细胞介素-2(IL)-2、IL-6、IL-10]水平与治疗后总有效率。结果 治疗前,两组免疫功能指标、IGF-2、STMN1、SCC、CYFRA21-1、血清Th1/Th2细胞相关因子水平差异无统计学意义(P> 0.05);较治疗前,两组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、STMN1、INF-γ、IL-2水平更高,CD8^(+)、IGF-2、SCC、CYFRA21-1、IL-6、IL-10水平更低,差异均有统计学意义(P <0.05);治疗后,研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、STMN1、INF-γ、IL-2水平高于对照组,CD8^(+)、IGF-2、SCC、CYFRA21-1、IL-6、IL-10水平低于对照组,差异均有统计学意义(P <0.05)。治疗后,研究组总有效率77.42%,高于对照组(48.39%),差异有统计学意义(P <0.05)。结论 子宫颈癌术后治疗中康艾注射液应用效果显著,其机制可能与增强患者免疫功能和改善其STMN1、CYFRA21-1、SCC、IGF-2与血清Th1/Th2细胞相关因子水平有关。Objective To study the effects of Kangai injection on immune function,insulin-like growth factor-2( IGF-2),recombinant human microtubule depolymerin-1( STMN1),squamous cell carcinoma associated antigen( SCC) of postoperative patients with cervical cancer.Methods A total of 62 cases of cervical cancer patients admitted to Qinhuangdao Maternal and Child Health Care Hospital from January2020 to June 2021 were retrospectively analyzed and divided into study group( n = 31) and control group( n = 31) according to treatment methods.Patients in both groups received neoadjuvant chemotherapy before surgery,and then underwent radical open cervical resection.The control group received conventional symptomatic treatment after surgery,and the research group received Kangai injection based on conventional therapy.The immune function indexes( CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),IGF-2,STMN1,SCC,cytokeratin 19 fragment antigen( CYFRA21-1) and serum Th1/Th2 cytokines [IFN-γ,interleukin( IL)-2,IL-6,IL-10] levels between the two groups before and after treatment and total response rate after treatment were compared.Results Before treatment,there were no significant differences in immune function indexes,IGF-2,STMN1,SCC,CYFRA21-1 and serum Th1/Th2 cytokines( P > 0.05).Compared with before treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),STMN1,INF-γ and IL-2 were higher after treatment,while the levels of CD8^(+),IGF-2,SCC,CYFRA21-1,IL-6 and IL-10 were lower in two groups,the differences were statistically significant( P < 0.05).After treatment,compared with the control group,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),STMN1,INF-γ,IL-2 were higher in the study group,while the levels of CD8^(+),IGF-2,SCC,CYFRA21-1,IL-6 and IL-10 were lower in the study group,the differences were statistically significant( P < 0.05).After treatment,the total effective rate in the study group was 77.42%,which was higher than that in the control group( 48.39%),and the difference was statistically significant( P < 0.05).Conclusion Kang’ai

关 键 词：子宫颈癌 康艾注射液 免疫功能 胰岛素样生长因子-2 重组人微管解聚蛋白-1 

分 类 号：R737.33[医药卫生—肿瘤]