外周血NLR、PLR、SCC、CA125和CYFRA21-1在早期宫颈鳞癌诊断中的价值  

Value of peripheral blood NLR,PLR,SCC,CA125 and CYFRA21-1 in diagnosis of early cervical squamous cell carcinoma

作　　者：李小琴[1] 宋楠昊 石永军 侯玉磊[1] LI Xiaoqin;SONG Nanhao;SHI Yongjun;HOU Yulei(Department of Clinical Laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;School of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016 [2]重庆医科大学检验医学院,重庆400016

出　　处：《检验医学与临床》2022年第10期1302-1305,共4页Laboratory Medicine and Clinic

基　　金：重庆市科卫联合医学科研项目(2021MSXM095)。

摘　　要：目的 探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、鳞状上皮细胞癌抗原(SCC)、糖类抗原125(CA125)和细胞角蛋白19片段(CYFRA21-1)在早期宫颈鳞癌诊断中的价值。方法 比较163例早期宫颈鳞癌患者(试验组)和171例健康对照者(对照组)的NLR、PLR、SCC、CA125和CYFRA21-1水平,分析各指标对早期宫颈鳞癌的诊断效能及其与肿瘤大小、肿瘤界限之间的关系。结果 试验组NLR、PLR、SCC、CA125和CYFRA21-1水平高于对照组(P<0.05)。受试者工作特征(ROC)曲线显示,NLR、PLR、SCC、CA125和CYFRA21-1 5项指标中单一诊断早期宫颈鳞癌以SCC诊断效能最大,曲线下面积为0.710,5项指标联合检测的曲线下面积、灵敏度、特异度分别为0.832、66.46%、93.57%。早期宫颈鳞癌肿瘤最大径≥2 cm组较肿瘤最大径<2 cm组的SCC和CA125水平升高,肿瘤超越子宫组较肿瘤未超越子宫组的SCC和CYFRA21-1水平升高(P<0.05)。结论 早期宫颈鳞癌患者NLR、PLR、SCC、CA125和CYFRA21-1水平升高,联合检测可提高诊断效能,SCC和CA125有助于早期宫颈鳞癌肿瘤大小的鉴别,SCC和CYFRA21-1有助于肿瘤界限的鉴别。Objective To investigate the value of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),squamous cell carcinoma antigen(SCC),carbohydrate antigen 125(CA125) and cytokeratin 19 fragment(CYFRA21-1) in the diagnosis of early cervical squamous cell carcinoma.Methods The levels of NLR,PLR,SCC,CA125 and CYFRA21-1 in 163 patients with early cervical squamous cell carcinoma(experimental group) and 171 healthy controls(control group) were compared,and the diagnostic efficacy of each indicator,their combined detection for early cervical squamous cell carcinoma and its relationship with tumor size and tumor boundary were analyzed.Results The NLR,PLR,SCC,CA125 and CYFRA21-1 in experimental group were higher than those in control group(P<0.05).The receiver operating characteristic(ROC) curve analysis showed that among NLR,PLR,SCC,CA125 and CYFRA21-1,the single diagnostic efficacy of SCC was the highest,with an area under the curve(AUC) was 0.710.The AUC,sensitivity and specificity of combined detection of these five indicators was 0.832,66.46%,and 93.57% respectively.The levels of SCC and CA125 in early cervical squamous cell carcinoma with maximum diameter ≥2 cm were higher than those in the group with maximum diameter <2 cm,and the levels of SCC and CYFRA21-1 were higher in the group with tumor boundaries beyond uterus than those in the group without tumor boundaries(P<0.05).Conclusion The NLR,PLR,SCC,CA125 and CYFRA21-1 are increased in patients with early cervical squamous cell carcinoma,and their combined detection could improve the diagnostic efficiency.SCC and CA125 are helpful for the identification of tumor size in early cervical squamous cell carcinoma,while SCC and CYFRA21-1 are helpful for the identification of tumor boundaries.

关 键 词：宫颈癌 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 鳞状上皮细胞癌抗原 糖类抗原125 细胞角蛋白19片段 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]