不同年龄段人群中非酒精性脂肪性肝病与高血压的相关性  

Association between non-alcoholic fatty liver disease and hypertension in different age groups

作　　者：吴英花 黄清志 钟新 全贞玉 WU Ying-hua;HUANG Qing-zhi;ZHONG Xin;QUAN Zhen-yu(Health Examination Center of Yanbian University Hospital,Yanji.Jilin 133000,China;Departnient of Preventive,School of Medicine,Yanbiati University)

机构地区：[1]延边大学附属医院健康体检中心,吉林延吉133000 [2]延边大学医学院预防医学教研部

出　　处：《中华高血压杂志》2022年第4期347-351,I0005,共6页Chinese Journal of Hypertension

基　　金：国家自然科学基金资助项目(81660562)。

摘　　要：目的 探讨不同年龄段非酒精性脂肪性肝病(NAFLD)与高血压的相关性。方法 在2017年6月至2018年8月间参与健康体检的年龄≥20岁成年人11 141名中入选符合条件者3 009人进行分析。根据《非酒精性脂肪性肝病诊疗指南(2010年修订版)》诊断NAFLD。采用logistic回归分析不同年龄段NAFLD与高血压的相关性。结果 青年、中年和老年NAFLD人群中高血压的检出率呈上升趋势(28.4%比40.3%比56.4%,χ^(2)=34.622,P;<0.001)。调整混杂因素后,多因素logistic回归分析显示,青年、中年和老年NAFLD人群高血压的患病风险分别是非NAFLD人群的3.17(95%CI 2.01~4.99)、2.72(95%CI 1.99~3.70)和1.98(95%CI 1.29~3.05)倍,且NAFLD与年龄在高血压的患病中存在交互作用(χ^(2)=156.012,P;<0.001)。结论 NAFLD与高血压的患病密切相关,不同年龄段人群中NAFLD对高血压患病的影响程度不同。Objective To investigate the association between the non-alcoholic fatty liver disease(NAFLD) and hypertension in subjects with different age. Methods A total of 3 009 eligible subjects were selected from 11 141 adults aged 20 years or above who participated in physical examination between June 2017 and August 2018. NAFLD was diagnosed according to the Guidelines for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease(2010 Revision). The correlation between NAFLD and hypertension in different age groups was analyzed by logistic regression. Results The prevalence of hypertension in young, middle-aged and elderly NAFLD subjects was 28.4%, 40.3% and 56.4% respectively, showing an upward trend(χ^(2)=34.622, P<0.001). After adjusting for the confounding factors, the risk of hypertension in young, middle-aged and elderly NAFLD population was 3.17(95%CI 2.01-4.99), 2.72(95%CI 1.99-3.70) and 1.98(95%CI 1.29-3.05)-fold of non NAFLD respectively as indicated by multivariate logistic analysis. In addition, there was an interaction between NAFLD and age in the incidence of hypertension(χ^(2)=156.012,P<0.001). Conclusions NAFLD is closely related to the incidence of hypertension, but the effect of NAFLD on hypertension is different in different age groups.

关 键 词：非酒精性脂肪性肝病 高血压 年龄 

分 类 号：R575.5[医药卫生—消化系统] R544.1[医药卫生—内科学]