BCH-2003方案和CCLG-2008方案对急性淋巴细胞白血病患儿SOCS3 mRNA、STAT3 mRNA的影响探究  

Effect of BCH-2003 and CCLG-2008 protocol on SOCS3 mRNA,STAT3 mRNA in children with acute lymphoblastic leukemia

作　　者：宋超 张雯[1] 钟镇阳 SONG Chao;ZHANG Wen;ZHONG Zhen-yang(Department of Hematology and Immunology,Affiliated Hospital of Yan'an University 716000,China)

机构地区：[1]延安大学附属医院血液免疫科,陕西延安716000

出　　处：《临床和实验医学杂志》2022年第7期702-705,共4页Journal of Clinical and Experimental Medicine

基　　金：陕西省教育厅自然科学研究项目(编号:16JK2031)。

摘　　要：目的探讨BCH-2003方案和CCLG-2008方案与急性淋巴细胞白血病(ALL)患儿细胞因子信号转导抑制因子3(SOCS3)mRNA以及信号转导和转录激活因子3(STAT3)mRNA的影响。方法选取2019年1月至2021年1月延安大学附属医院收治的ALL患儿(分子生物学标记为TEL-AMLI)78例进行回顾性分析,根据干预方案不同分成BCH-2003方案组和CCLG-2008方案组,各39例。比较两种治疗方案初诊时、治疗后的SOCS3 mRNA、STAT3 mRNA表达和SOCS3 mRNA、STAT3 mRNA的相关性。BCH-2003方案和CCLG-2008方案的差异性。结果初诊时、治疗后,两组ALL患儿的SOCS3 mRNA、STAT3 mRNA水平比较,差异均无统计学意义(P>0.05);治疗后,两组ALL患儿SOCS3 mRNA均显著升高,STAT3 mRNA显著降低,恢复至正常表达水平,差异均有统计学意义(P<0.05)。ALL患儿病变组织中的SOCS3与STAT3表达呈负相关(r=-0.597,P<0.05)。BCH-2003方案组预后复发的危险性、免疫分型、复发部位等指标占比均高于CCLG-2008方案组,差异均有统计学意义(P<0.05)。结论BCH-2003方案和CCLG-2008方案对ALL患儿病变组织中的SOCS3及STAT3mRNA表达有调节作用,短期临床疗效均较好,CCLG-2008方案的预后复发严重性较BCH-2003方案偏低。Objective To explore the influence of BCH-2003 protocol and CCLG-2008 protocol and cytokine signal transduction inhibitor 3(SOCS3)mRNA and signal transcription activation factor 3(STAT3)mRNA in children with acute lymphocytic leukemia(ALL).Methods A total of 78 children with ALL(molecular biological marker TEL-AMLI)admitted to the Affiliated Hospital of Yan'an University from January 2019 to January 2021 were retrospectively selected and divided into BCH-2003 group and CCLG-2008 program group according to the intervention protocol,each with 39 cases.The correlation of SOCS3 mRNA and STAT3 mRNA expression and SOCS3 mRNA and STAT3 mRNA expression at the initial diagnosis and after treatment of the two treatment regimens were compared.The differences between the BCH-2003 scheme and the CCLG-2008 scheme were compared.Results At the initial diagnosis and after treatment,there was no significant difference in the levels of SOCS3 mRNA and STAT3 mRNA between the two groups of children with ALL(P>0.05).After treatment,the SOCS3 mRNA in the two groups of ALL children was significantly increased,and the STAT3 mRNA was significantly decreased,and returned to the normal expression level,the differences were statistically significant(P<0.05).SOCS3 was negatively associated with STAT3 expression in children with ALL(r=-0.597,P<0.05).The proportion of prognosis recurrence risk,immune typing,recurrence site and other indicators in BCH-2003 group were higher than those in CCLG-2008 group,the differences were statistically significant(P<0.05).Conclusion BCH-2003 and CCLG-2008 regulate the SOCS3 mRNA and STAT3 mRNA expression in ALL,with good short-term clinical effect,and the prognosis severity of CCLG-2008 was lower than that of BCH-2003.

关 键 词：急性淋巴细胞白血病 BCH-2003方案 CCLG-2008方案 SOCS3 STAT3 

分 类 号：R733.71[医药卫生—肿瘤]