弹性髓内钉并病灶刮除联合自体骨髓加异体骨粉移植对儿童肱骨近端骨囊肿的疗效  

Efficacy of elastic intramedullary nail and lesion curettage combined with autologous bone marrow and allogeneic bone powder transplantation in treatment of proximal humeral bone cysts in children

作　　者：唐崧杰 崔红旺 王挺锐[1] TANG Songjie;CUI Hongwang;WANG Tingrui(Department of Spinal osteopathy,the First Affiliated Hospital of Hainan Medical University,Haikou 570000,China)

机构地区：[1]海南医学院第一附属医院脊柱骨病外科,海口570000

出　　处：《实用医学杂志》2022年第7期853-856,862,共5页The Journal of Practical Medicine

基　　金：2017年度国家级地区科学基金项目(编号:81760260)。

摘　　要：目的 探究弹性髓内钉并病灶刮除联合自体骨髓加异体骨粉移植对儿童肱骨近端骨囊肿的疗效。方法 回顾性分析2018年7月至2020年9月于我院接受弹性髓内钉并病灶刮除联合自体骨髓加异体骨粉移植治疗的56例肱骨近端骨囊肿患儿的临床资料,设为观察组(n=56),再将同期于我院行单一病灶刮除联合自体骨髓加异体骨粉移植治疗的51例患儿临床资料纳入对照组(n=51)。比较两组患儿术后疗效、治愈时间差异,探究两组患儿并发症情况差异,分析两组患儿术前、术后6个月时肢体功能[国际骨肿瘤协会(MSTS)功能评分]、生活质量[儿童生活质量普适性量表(PedsQLTM 4.0)]差异。结果 术后6个月时,观察组患儿治愈率高于对照组,观察组患儿治愈时间低于对照组(均P <0.05);随访6个月期间,两组患儿治疗并发症发生率差异无统计学意义(均P> 0.05)。术后6个月时,两组患儿MSTS、PedsQLTM 4.0得分均较术前上升,且观察组患儿高于对照组(均P <0.05)。结论 弹性髓内钉并病灶刮除联合自体骨髓加异体骨粉移植治疗儿童肱骨近端骨囊肿的疗效显著,可促进患儿治愈时间缩短,改善患儿肢体功能,提升患儿生存质量,且不会导致并发症增加。Objective To explore the efficacy of elastic intramedullary nail and lesion curettage combined with autologous bone marrow and allogeneic bone powder transplantation in the treatment of proximal humeral bone cysts in children.Methods A retrospective analysis was performed on the clinical data of 56 children(observation group)with proximal humeral bone cysts who received elastic intramedullary nail and lesion curettage combined with autologous bone marrow and allogeneic bone powder transplantation in our hospital between July 2018 and September 2020,and the clinical data of 51 children who underwent single lesion curettage combined with autologous bone marrow and allogeneic bone powder transplantation in our hospital during the same period were included in control group(n = 51).The differences in postoperative efficacy and healing time were compared between the two groups;the complications were explored in the two groups,and the differences in limb function[Musculoskeletal Tumor Society(MSTS)function score]and quality of life[Pediatric Quality of Life Inventory TM version 4.0(PedsQLTM 4.0)]of the two groups were analyzed before surgery and 6 months after surgery.Results Six months after surgery,the cure rate of children in the observation group was higher than that of the control group,and the cure time of children in observation group was shorter than that of control group(all P < 0.05).There were no significant differences in the incidence rates of treatment complications between the two groups during 6 months of follow-up(all P > 0.05).Six months after surgery,the scores of MSTS and PedsQLTM 4.0 of the two groups were increased when compared with those before surgery,and the scores in observation group were higher than those in control group(all P < 0.05).Conclusion Elastic intramedullary nail and lesion curettage combined with autologous bone marrow and allogeneic bone powder transplantation has a significant efficacy in the treatment of proximal humeral bone cysts in children,and it shortens the healing time

关 键 词：弹性髓内钉 病灶刮除 自体骨髓 儿童 骨囊肿 肱骨近端 

分 类 号：R738.1[医药卫生—肿瘤]