以帕金森症状为主要表现的抗突触蛋白-3α抗体相关脑炎1例  

Anti-neurexin-3αantibody-associated encephalitis with parkinsonism as the main manifestation:a case report

作　　者：郑合情 吴兰香 田胜 刘盼 刘明煦 吴伟[1] Zheng Heqing;Wu Lanxiang;Tian Sheng;Liu Pan;Liu Mingxu;Wu Wei(Department of Neurology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院神经内科,南昌330006

出　　处：《中华神经科杂志》2022年第5期497-500,共4页Chinese Journal of Neurology

摘　　要：抗突触蛋白-3α抗体相关脑炎临床罕见,多有前驱感染史,以精神行为异常、癫痫发作、意识水平下降、认知及睡眠障碍、运动障碍、中枢性低通气及自主神经功能障碍等症状为主。其中,运动障碍主要为口面部及肢体的不自主运动、肌张力障碍、肌阵挛样发作等运动增多表现,表现为运动减少的帕金森症状罕见报道。现报道1例抗突触蛋白-3α抗体阳性的脑炎患者,为青年女性,以运动迟缓、行走不稳、起步及转身困难、双上肢持物不能的帕金森症状为主要表现,伴精神行为异常、认知功能障碍,经甲泼尼龙及静脉注射免疫球蛋白治疗后,预后良好。Anti-neurexin-3αantibody-associated encephalitis is rare in clinical practice.It often has a history of pre-infection.It is characterized by abnormal mental behavior,seizures,decreased consciousness,cognitive and sleep disorders,movement disorder,central hypoventilation and autonomic nervous dysfunction.Among them,dyskinesias are mainly involuntary movements of the mouth,face and limbs,dystonia,myoclonic seizures and other manifestations of increased movement.Parkinson′s symptoms manifested as decreased movement are rarely reported.A encephalitis patient with positive anti-neurexin-3αantibody is reported,who is a young female,mainly with parkinsonism such as slow movement,unsteady walking,difficulty in starting and turning around,and inability to hold things in both upper limbs,accompanied by abnormal mental behavior and cognitive dysfunction.After treatment with methylprednisolone and intravenous immunoglobulin,the prognosis is good.

关 键 词：神经系统自身免疫疾病 突触蛋白类 帕金森障碍 抗体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]