补体靶向治疗在神经系统自身免疫性疾病中的应用  

The application of complement-targeted therapies in autoimmune diseases of nervous system

作　　者：谢竹霄 刘磊[1] 王佳伟[2] Xie Zhuxiao;Liu Lei;Wang Jiawei(Department of Neurology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Medical Research Center,Department of Neurology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院神经内科,北京100730 [2]首都医科大学附属北京同仁医院神经内科中心实验室,北京100730

出　　处：《中华神经科杂志》2022年第5期536-543,共8页Chinese Journal of Neurology

基　　金：国家自然科学基金面上项目(81771313);国家自然科学基金青年基金(81301029);北京市医院管理局“青苗”计划专项(QML20150206);北京市自然科学基金面上项目(7192040);北京市科技计划课题“首都特色”项目(Z1771100001017039);首都卫生发展科研专项(2020-2-2056)。

摘　　要：补体是机体免疫系统的重要组成部分,在免疫监视和组织稳态中起着至关重要的作用。越来越多的证据表明,补体激活不仅可以对机体产生保护作用,而且参与多种自身免疫性疾病的发生和发展。补体激活不当会导致或加重视神经脊髓炎谱系疾病、重症肌无力以及吉兰-巴雷综合征等多种神经系统自身免疫性疾病。近年来,随着对补体的认识不断加深,补体靶向治疗也成为众多自身免疫性疾病的临床研究热点。文中通过介绍补体参与神经系统自身免疫病的具体机制以及补体靶向治疗的最新进展,希望能够对该新兴治疗领域的发展起到抛砖引玉的作用。Complement is an important element of immune system playing vital roles in immune surveillance and tissue homeostasis.Increasing evidence shows that complement activations not only protect the body,but contribute to the occurrence and development of autoimmune diseases.Inappropriate activations of complement may also lead to or aggravate various neuro-immunological diseases,including neuromyelitis optica spectrum disease,myasthenia gravis and Guillain-Barrésyndrome.Several complement-targeted therapeutics have emerged in recent years,established themselves as popular clinical research topics associated with various autoimmune diseases.Following that note,this review introduces mechanisms of complements participating in autoimmune diseases of the nervous system and the latest development of complement-targeted therapeutics,with the view to contributing to the development of this emerging therapeutic field.

关 键 词：补体系统蛋白质类 重症肌无力 视神经脊髓炎 吉兰-巴雷综合征 

分 类 号：R741[医药卫生—神经病学与精神病学]