第二代结肠胶囊内镜在体检人群胃肠道疾病诊断中的初步应用  

Preliminary application of the second-generation capsule endoscopy in the diagnosis of gastrointestinal diseases in health examination population

作　　者：熊艺琳 宋军[1] 朱良如[1] 侯晓华[1] 谢小平[1] XIONG Yi-lin;SONG Jun;ZHU Liang-ru;HOU Xiao-hua;XIE Xiaoping(Department of Gastroenterology,Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology,430022 Wuhan,China)

机构地区：[1]华中科技大学协和医院消化内科,湖北武汉430022

出　　处：《临床消化病杂志》2022年第2期92-95,共4页Chinese Journal of Clinical Gastroenterology

基　　金：国家重点研发计划资助(No.2018YFC0114600)。

摘　　要：[目的]探讨第二代结肠胶囊内镜(Second-generation colon capsule endoscopy, CCE-2)在体检人群胃肠道疾病筛查中的初步应用。[方法]纳入行CCE-2检查的体检人群160例。由具有结肠胶囊内镜丰富判读经验的消化内科医师分析检查结果,观察CCE-2在胃、小肠和结肠的通过时间,以及胶囊检查完成率、病变检出情况。[结果]81.9%(131/160)的患者在胶囊运行时间内完成全消化道检查,胃通过时间为(0.90±0.78)h,小肠通过时间为(2.06±1.08)h,结肠通过时间为(5.52±4.72)h,完成全消化道检查患者的胶囊运行时间短于未完成全消化道检查者,差异有统计学意义(t=7.659,P<0.01)。CCE-2共发现145例(90.6%)消化道病变,其中有11例(6.9%)食管病变,包括反流性食管炎、多发隆起性病变和食管新生物;115例(71.9%)胃病变,包括胃炎、胃息肉;28例(17.5%)十二指肠病变,包括十二指肠球炎、溃疡、隆起性病变和憩室;48例(30.0%)小肠病变,包括炎症、溃疡、息肉、隆起性病变;98例(61.3%)结直肠病变,包括炎症、息肉和憩室。[结论]CCE-2对胃肠道病变有较高的发现率,尤其对不愿行结肠镜检查的体检人群,CCE-2是可以选择的筛查手段之一。[Objective]To explore the application of the second-generation colon capsule endoscopy(CCE-2)in screening of gastrointestinal diseases in health examination population.[Methods]From 2017 to 2019,at Wuhan Union Hospital, 160 general persons who underwent CCE-2 examination were enrolled.The examination results were analyzed by an skillful gastroenterologist with rich experience in colon capsule endoscopy.The stomach, small bowel and colon transit time, the completion rate of capsule examination and detection of lesions were observed.Chi-square test and t test were used for statistical analysis.[Results]The whole gastrointestinal tract examination was completed during the capsule running time in 81.9%(131/160)of the subjects.The average stomach empty time was(0.90±0.78)h, the small bowel transit time was(2.06±1.08)h and the colon transit time was(5.52±4.72)h.The capsule running time in subjects who completed the whole gastrointestinal tract examination was shorter than that of subjects who did not complete the whole gastrointestinal tract examination, and the difference was statistically significant(t=7.659,P<0.01).CCE-2 found 145 lesions(90.6%),including 12 esophageal lesions(reflux esophagitis, multiple protuberant lesions and esophageal neoplasia)(6.9%),115 gastric lesions(gastritis and polyps)(71.9%),28 duodenal lesions(duodenitis, ulcer, protuberant lesion and diverticulum)(17.5%),48 small intestinal lesions(inflammation, ulcers, polyps and protuberant lesions)(30%)and 98 colorectal lesions(inflammation, diverticulum and polyps)(61.3%).[Conclusion]CCE-2 has a high detection rate of intestinal lesions.CCE-2 is one of the optional screening methods for people who do not want to undergo colonoscopy.

关 键 词：第二代结肠胶囊内镜 体检人群 胃肠道疾病 

分 类 号：R730.49[医药卫生—肿瘤]